Results 141 to 150 of about 709,838 (360)

Red Blood Cell Membrane‐Camouflaged Red Phosphorus‐Modified C3N4 for Enhanced Tumoral Photodynamic Therapy

Advanced Materials Interfaces, EarlyView.
Photodynamic therapy (PDT) faces clinical challenges due to poor tumor targeting and systemic toxicity. Herein, a biomimetic C3N4‐RP@RBCm nanoplatform is developed via erythrocyte membrane encapsulation, enabling CD47‐mediated immune evasion and EPR‐driven tumor accumulation.
Jiaxiu Liu, Jingying Chen, Tianyang Li, Pingping Meng, Xitong Lin, Yuting Zhai, Yukun Zhu, Daohao Li, Dongjiang Yang, Shuchao Zhang   +9 more
wiley   +1 more source

Outcomes of definitive radiotherapy vs. laryngectomy followed by adjuvant radiotherapy in patients with locally advanced laryngeal squamous cell carcinoma: real-world experience in a referral cancer center

Radiation Oncology
Background Laryngeal cancer is a common head and neck cancer. Surgical treatment can impair patients’ voice and swallowing function, making definitive radiotherapy a viable alternative for locally advanced cases.
Ali Kazemian, Ebrahim Esmati, Reza Ghalehtaki, Borna Farazmand, Nima Mousavi-Darzikolaee, Reyhaneh Bayani, Mahdieh Razmkhah, Maryam Taherioun, Niloufar Saeedi, Farrokh Heidari, Kaveh Zakeri   +10 more
doaj   +1 more source

Novel digital tissue phenotypic signatures of distant metastasis in colorectal cancer [PDF]

arXiv, 2018
Distant metastasis is the major cause of death in colorectal cancer (CRC). Patients at high risk of developing distant metastasis could benefit from appropriate adjuvant and follow-up treatments if stratified accurately at an early stage of the disease.
arxiv  

High PD-L1 expression is associated with a favorable prognosis in patients with esophageal squamous cell carcinoma undergoing postoperative adjuvant radiotherapy

Oncology Letters, 2018
Previous results on the prognostic value of programmed death-ligand (PD-L)1 expression in patients with esophageal squamous cell carcinoma (ESCC) remain limited and conflicting.
Chenxue Jiang, Yaoyao Zhu, S. Tang, Gu Zhang, Q. Lin, Ya-ping Xu, J. Shang   +6 more
semanticscholar   +1 more source

Transplantable melanomas in hamsters and gerbils as models for human melanoma : sensitization in melanoma radiotherapy : from animal models to clinical trials [PDF]

, 2018
The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption
Andrzej Słominski, Anna Brożyna, Anna Markiewicz, Bożena Romanowska-Dixon, Ewa Podgórska, Krystyna Urbańska, Martyna Elas, Martyna Śniegocka, Małgorzata Szczygieł, Michał Żmijewski, Mirosława Cichorek, Przemysław Płonka   +11 more
core   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Adjuvant Carboplatin and Paclitaxel Chemotherapy Followed by Radiotherapy in High-Risk Endometrial Cancer: A Retrospective Analysis

Journal of Global Oncology, 2018
Purpose: The best adjuvant treatment in high-risk endometrial cancer remains unclear. Although adjuvant chemotherapy seems to improve overall survival (OS) in locally advanced disease, the role of adding radiotherapy is not certain.
Renata Rodrigues da Cunha Colombo Bonadio, Renata Gondim Meira Velame Azevedo, Guilherme Harada, Samantha Cabral Severino da Costa, Vanessa Costa Miranda, Daniela de Freitas, Elias Abdo Filho, Patricia Alves de Oliveira Ferreira, Flavia Gabrielli, Maria Del Pilar Estevez Diz   +9 more
doaj   +1 more source

Impact of Delayed Adjuvant Radiotherapy in the Survival of Women with Breast Cancer

Cureus, 2018
Objective Our objective was to determine whether a delay in adjuvant radiotherapy is related to a decrease in relapse-free survival and disease-specific survival of women with operable breast cancer.
C. Flores-Balcázar, L. Flores-Luna, C. Villarreal-Garza, A. Mota-García, E. Bargalló-Rocha   +4 more
semanticscholar   +1 more source

Current Oncological Treatment of Patients with Pancreatic Cancer in Germany: Results from a National Survey on behalf of the Arbeitsgemeinschaft Internistische Onkologie and the Chirurgische Arbeitsgemeinschaft Onkologie of the Germany Cancer Society [PDF]

, 2009
Background: No data have previously been available regarding the current treatment of patients with pancreatic cancer (PC) in German hospitals and medical practices.
Boeck, Stefan, Bruns, Christiane J., Heinemann, Volker, Jauch, Karl-Walter, Sargent, Mirja, Schäfer, Claus, Seufferlein, Thomas   +6 more
core   +1 more source

Targeting Splenic Myeloid Cells with Nanobiologics to Prevent Postablative Pancreatic Cancer Recurrence via Inducing Antitumor Peripheral Trained Immunity

Advanced Science, EarlyView.
Using a preclinical pancreatic cancer model, we identified that tumor progression restructures splenic immunity via myeloid cell expansion. MDCa@RBC‐Alipo nanobiologics were engineered to epigenetically and metabolically reprogram splenic myeloid cells, alleviating post‐ablation immunosuppression.
Shengbo Wu, Weichen Xu, Xuexia Shan, Liping Sun, Shuo Liu, Xixi Sun, Shaoyue Li, Xiaodong Hou, Xiaowan Bo, Chengzhong Peng, Bin Huang, Huixiong Xu, Wenwen Yue   +12 more
wiley   +1 more source