Results 211 to 220 of about 488,339 (301)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Utilization of immune checkpoint inhibitors for the treatment of cancer in Scotland, 2018–2024: A national retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of the study is to describe the use of immune checkpoint inhibitors (ICIs) for the treatment of cancer in Scotland. Methods The retrospective observational cohort study included patients aged 18 years or older who commenced treatment with an ICI in Scotland between 1 January 2018 and 31 December 2024.
Tanja Mueller, Christine Crearie, Liya Lu, Jiafeng Pan, Fraser N. Sneden, David Martin, Amanj Kurdi, Catherine S. Thomson, Julie Clarke, Marion Bennie   +9 more
wiley   +1 more source

Creating Virtual Intraoperative CT Images From Endoscopic Video During Endoscopic Sinus Surgery: A Proof‐of‐Concept Study

International Forum of Allergy &Rhinology, EarlyView.
Graham J. Harris, Nicole Gunderson, Jeremy Ruthberg, Pengcheng Chen, Eric J. Seibel, Randall Bly, Waleed M. Abuzeid   +6 more
wiley   +1 more source

The potential impact of H1 antihistamines on clinical outcomes in NSCLC patients undergoing EGFR‐TKIs treatment

British Journal of Clinical Pharmacology, EarlyView.
Background Epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) have substantially improved outcomes in non‐small cell lung cancer (NSCLC); however, the development of treatment resistance remains a major clinical challenge. This study examines the association between concomitant prescriptions of H1‐antihistamines (H1AHs) and ...
Van Thuan Nguyen, Ngoc Hoang Le, Nhu Quynh Phan, Toan Trung Duong, Le Thi Anh Thu, Hsuan‐Chia Yang, Chih‐Wei Huang, Min‐Huei Hsu, Jason C. Hsu, Chien‐Tien Su, Phung‐Anh Nguyen   +10 more
wiley   +1 more source

Factors associated with grade ≥2 acute radiation dermatitis after adjuvant radiotherapy in breast cancer patients with immediate breast reconstruction: a single-center study using penalized regression. [PDF]

Front Oncol
Liu Y, Duan X, Wang C, Li Y, Wu Y, He Z, Lian P, Li N, Zhang X, Zhao J.   +9 more
europepmc   +1 more source

Elongated inflamed uvula mimicking early recurrence on planning CT in post-laryngectomy laryngeal squamous cell carcinoma: a diagnostic pitfall in adjuvant radiotherapy. [PDF]

Oxf Med Case Reports
Bouanane R, Taibi O, El Aouadi S, Laamrani FZ, Omor Y, Latib R, Amalik S, Skitioui I, Ichou S, Majdi A, Lachgar A, Nouni K, ElKacemi H, Kebdani T, Hassouni K.   +14 more
europepmc   +1 more source

Short-Term Symptom and Functional Outcomes Following Definitive Chemoradiotherapy Versus Surgery Plus Adjuvant Radiotherapy in Locally Advanced Oral Cavity Squamous Cell Carcinoma. [PDF]

Cureus
Taher S, Islam A, Hossain A, Ahsan Rony MM, Faruque MO, Afreen C, Das A, Hossain T, Mou MR, Hasan Chowdhury MM.   +9 more
europepmc   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Single-session transanal minimally invasive surgery (TAMIS) and adjuvant radiotherapy in a patient with three synchronous early rectal adenocarcinomas: a video vignette. [PDF]

Tech Coloproctol
Maden A, Shussman N, Wygoda M, Mizrahi I.   +3 more
europepmc   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source