Results 151 to 160 of about 2,696,581 (351)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Effect of the inhalation of nitric oxide on 5-hydroxytryptamine-induced pulmonary hypertension in calves

, 1996
In healthy anaesthetized Friesian-Holstein calves, pulmonary hypertension was induced ly means of a continuous intravenous administration of serotonin (0.025 mg/kg body/weight/min).
Sustronck, Bart, Muylle, Etienne, G. Van Loon, F. Gasthuys, Deprez, Piet, E. Muylle, B. Sustronck, P. Deprez, Gasthuys, Frank, van Loon, Gunther, FOUBERT, L, L. Foubert   +11 more
core   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Water-soluble proteins as an excipient for drug administration by inhalation

, 2020
© 2020, Springer Science+Business Media LLC. Microspherical particles of composite drugs based on lysozyme and albumin, which can be used in inhalation administration, were prepared by spray drying.
Ziganshin M.A., Gerasimov A.V., Boldyrev A.E., Klimovitskii A.E., Lyadov N.M.   +4 more
core  

Dumbbell‐Structured Plasmonic‐Enhanced Optical Nanoprobes Boosting Photo‐Magnetic‐Acoustic Multimodal Imaging‐Guided Photodynamic‐Photothermal Synergistic Treatment and Immunogenic Death in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study reports a novel rationally‐designed optical nanoprobe based on dumbbell‐shaped mesoporous silica‐coated gold nanorods, loaded with rare‐earth oxides, photosensitizers, and tumor‐targeted peptides, enabling plasmonic‐enhanced multimodal imaging and PTT‐PDT synergy.
Baikang Zhuang, Yubiao Yang, Wen Han, Yi Tang, Chengxin Yao, Fuli Zhao, Wenxiao Fang, Jinjie Li, Xiaolan Huo, Yiqian An, Yuanzhi Shao, Botao Gao, Jinchang Yin   +12 more
wiley   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Exogenous GM-CSF therapy for autoimmune pulmonary alveolar proteinosis: a systematic literature review

Frontiers in Medicine
BackgroundGranulocyte-macrophage colony-stimulating factor (GM-CSF) therapy is an important treatment for autoimmune pulmonary alveolar proteinosis (aPAP).
Wushu Chen, Wushu Chen, Xin Feng, Lun-kai Yao, Xingpei Li, Zhen-ming Yang, Xiu-yu Qin, Yu Li, Ye Qiu   +8 more
doaj   +1 more source

The Relationship between Health Literacy and Self Administration of Inhalation Therapy in Patients with Obstructive Lung Diseases

The aim of this study was to explore health literacy and level of knowledge regarding the administration of inhaled medications of patients with obstructive lung diseases.
Lovrić, Božica, Mamić, Marin, Markota, Gabrijela, Samaržija, Matea, Maričević, Goran, Šimleša, Dinko, Vukoja, Ivan, Bardak, Darija   +7 more
core   +1 more source

Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol

, 2000
Repeated oral administration of chemopreventive retinoids such as isotretinoin over extended periods of time is associated with intolerable systemic toxicity. Here isotretinoin was formulated as a powder aerosol, and its delivery to the lungs of rats was
Staniforth, J N, Silvester, J, Raleigh, Stuart M, P Carthew, U Pastorino, Lim, C K, J N Staniforth, J Silvester, Pastorino, U, Gescher, A, R D Verschoyle, Dinsdale, D, C K Lim, A Gescher, S M Raleigh, Bowskill, C, F Steele, D Dinsdale, C Bowskill, Verschoyle, R D, Steele, F, Carthew, P   +21 more
core   +1 more source