Results 211 to 220 of about 2,070,422 (305)

From Pharmacological Uncertainty to Inhalation Development: An Evidence-Gated Roadmap for <i>Codonopsis</i>-Derived Triterpenoid Saponins. [PDF]

Drug Des Devel Ther
Zhang X, Yang C, Wang P, Yang P, Liu S, Liu S, Yang X.   +6 more
europepmc   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Integrating in vitro aerosol characterization and cross-species PBPK modeling to predict human lung exposure of inhaled therapeutic proteins. [PDF]

Int J Pharm X
Liu JL, Liu YX, Zhang XJ, Wang GL, Huang J, Zhang HF, Xu N, Zhang SN, Yue X, Liang XX, Luo YJ, Peng HX, Pei Q, Kuang Y, Yang GP.   +14 more
europepmc   +1 more source

Refining OVCAR‐3 xenograft models of peritoneal carcinomatosis in nu/nu mice: Comparative intraperitoneal implantation strategies and the role of basement membrane matrix

Animal Models and Experimental Medicine, EarlyView.
A refined murine model of advanced ovarian cancer was established by comparing localized preperitoneal implantation and intraperitoneal injection of OVCAR‐3Luc cells. While localized implantation showed limited tumor persistence, intraperitoneal delivery with BME produced sustained diffuse dissemination confirmed by BLI and histology, providing a ...
M. Teresa Perelló‐Trias, Antonio Jose Serrano‐Muñoz, Juan J. Segura‐Sampedro, Adriana M. Quintero‐Duarte, Joana M. Ramis, Marta Monjo   +5 more
wiley   +1 more source

Selection of Priority VOC Emission Sources in Seoul by Comparing Source Contributions and Health Risk-Based Contributions. [PDF]

Toxics
Jung JY, Park SY, Shin DS, Yoon JC, Lim HM, Kim KR, Oh SR, Choi YS, Cho HS, Lee CM.   +9 more
europepmc   +1 more source

Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context

Animal Models and Experimental Medicine, EarlyView.
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Osayd Zohud, Aysar Nashef, Imad Abu‐Elnaaj, Fuad A. Iraqi   +3 more
wiley   +1 more source

Mucosal boosting of chimpanzee adenovirus-vectored vaccine encoding SARS-CoV-2 RBD-heterodimer provides robust protection in mice. [PDF]

mBio
Liu X, An Y, Duan H, Shao F, Xu K, Yang C, Xu S, Zhou X, Duan M, Zheng T, Sun S, Yang M, Cai K, Liu WJ, Zhou D, Xu K, Dai L, Wang S, Liu P, Ma W, Gao GF.   +20 more
europepmc   +1 more source

A self‐retaining mouth prop for intraoral access during periodontal surgery in rat models: A technical note

Animal Models and Experimental Medicine, EarlyView.
A mouth prop designed to mimic the oral cavity of rats was made that provided stable, self‐retaining retraction, thereby facilitating oral surgery on rodents. Compared to conventional methods, it decreased surgical time, operator fatigue, and slippage. Its use led to higher efficiency and fewer complications and it was cost effective to produce.
Saravanan Sampoornam Pape Reddy, Delfin Lovelina Francis, Vivek Kumar Thakur, Balaji Manohar, Shaili Pradhan, Shesh Rai   +5 more
wiley   +1 more source

From injection to inhalation: A STING-activating mucosal adjuvant reprograms vaccination. [PDF]

Clin Transl Med
Wang W, Wang M, Lu L, Jiang S, Liu Z.
europepmc   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source