Results 241 to 250 of about 220,199 (312)

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

The Toxic Effects of Hydrated Cement, Autoclaved Aerated Concrete, and Demolition Dusts on the Respiratory System in Rats. [PDF]

Toxics
Kilic M, Gokturk N, Vardi N, Ozhan O, Koca G, Turkoz MA, Biyikli M, Turgut P, Turkoz Y, Parlakpinar H, Karadag E, Colak C.   +11 more
europepmc   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Inhalation & intravenous: umbilical cord mesenchymal stem cell-derived exosomes therapy strategy for acute respiratory distress syndrome in a murine model. [PDF]

J Thorac Dis
Yang L, Cao Z, Xing Y, Pan Y, Yang C, Zhang L, Zhao H, Ma T, Ye H.   +8 more
europepmc   +1 more source

Clarifying the neural circuit mechanisms of spontaneous social behavior in macaques. [PDF]

Front Neural Circuits
Ninomiya T, Kaneko T, Ono Y, Kobayashi K, Isoda M.   +4 more
europepmc   +1 more source

In vitro characterisation of fluticasone propionate and ciclesonide delivered with and without valved holding chambers using cascade impaction and an adult simulated breathing profile. [PDF]

BMJ Open Respir Res
Csonka LL, Lehtimäki L, Csonka P.
europepmc   +1 more source

Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice. [PDF]

Int J Mol Sci
Hori F, Sobue S, Inoue C, Murakumo Y, Ichihara M.   +4 more
europepmc   +1 more source

Mitochondrial Ultrastructure, Fission Proteins, Activity, and Motor Dysfunctions in the Innovative Parkinson's Disease Model Induced by Manganese Inhalation. [PDF]

Toxics
Garcia-Caballero CA, Ordoñez-Librado JL, De Alba-Ríos A, Montiel-Flores E, Aparicio-Trejo OE, García-Arroyo F, Cuevas-Lopez B, Pedraza-Chaverri J, Rodríguez-Lara V, Tron-Alvarez R, Gutierréz-Valdez AL, Sánchez-Betancourt J, Reynoso-Erazo L, Avila-Costa MR.   +13 more
europepmc   +1 more source

Exploring clinician and patient perspectives on choice of general anaesthetic. A report of two U.S. surveys: an anesthesia clinician Multicenter Perioperative Outcomes Group survey and a patient Amazon Mechanical Turk survey. [PDF]

BJA Open
Holzer KJ, Hurwitz RM, Tellor Pennington BR, Politi MC, Vaughn MT, Chu L, Price A, Hicks M, Avidan MS, Kheterpal S.   +9 more
europepmc   +1 more source