Results 191 to 200 of about 3,926,222 (296)

A self-triggering and fully sustainable gastric device enabling long-acting oral delivery of macromolecules. [PDF]

Sci Adv
Lu C, Yi Z, Yuan H, Wang H, Lei K, Li W, Wu X, Liu W, Zhang Y, Dong T, Wu K, Wang Y, Cui S, Zhao Y, He Y, Cheang UK, Liu T, Zhang Y, Ci T, Yang Y, Liang X.   +20 more
europepmc   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

Intravenous versus oral tranexamic acid in shoulder arthroplasty. [PDF]

Arch Orthop Trauma Surg
Parmar T, Adio A, Daher M, Khan A, Horneff J, Abboud J.   +5 more
europepmc   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Effects of Intraoral, Intracrop, and Intragastric Administration of Copper Sulfate on Vomiting, Retching Behavior, and Nausea-Like Responses in Chicks. [PDF]

J Poult Sci
Tachibana T, Nakamura K, Khan S, Cline MA.   +3 more
europepmc   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Modeling of Di(2-ethylhexyl) Adipate and Its Primary Metabolite, Mono(2-ethylhexyl) Adipate, in Rats, Incorporating Circulatory Topology-Based Multi-Tissue Metabolism and Lymphatic Absorption. [PDF]

Pharmaceutics
Yang E, Jeong YS, Kim M, Kim S, Chung SJ.   +4 more
europepmc   +1 more source

Coupled Electronic and Ionic Conductivity in Strain‐Stiffening Hydrogels

Advanced Science, EarlyView.
A soft PVA–PABA hydrogel is developed that couples tissue‐like strain‐stiffening mechanics with dual ionic–electronic conduction. Dynamic boronic crosslinks enable self‐assembled percolative pathways, producing deformation‐responsive resistance with a stabilization plateau at stiffening onset, revealing alignment‐assisted charge transport and advancing
Md Al Raihan, Mark M. A. Mikhail, Khaled M. Hijazi, Hessameddin Yaghoobi, John P. Frampton, Vahid Adibnia, Michael S. Freund   +6 more
wiley   +1 more source

Pharmacokinetics and Tissue Distribution in Rats After Oral Administration of Tibetan Medicine Wuwei Leze Powder. [PDF]

Chem Biodivers
Wang P, Wang P, Wu Y, Wu S, Xu H, Yang W, Tu Y, Liu C.   +7 more
europepmc   +1 more source