Results 181 to 190 of about 3,501,089 (247)

Patterns and determinants of medication use by paramedics in German prehospital emergency care: a six-year multicenter analysis. [PDF]

BMC Emerg Med
Hohenstein C, Nix SW.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Co-production of informal settlement health: a community based participatory research program for building healthy communities in urban informal settlements of Salvador, Brazil. [PDF]

Front Public Health
Mogaji H, Alexandra Alzate LY, Figuerêdo LA, Araujo Virgens JH, Aliaga MA, Argibay HD, Salles I, Pereira Moreira A, Lima E Silva TJ, Cristina Dos Santos S, Batista R, Cardoso E, Neves Santos EC, Leal Dos Santos E, Rodrigues Dos Santos E, da Mata Barreto T, Dos Santos Mattos TA, Nery N, Cruz J, Carneiro I, Lustosa R, Dedavid Ferreira VC, Reis M, Ko AI, Costa F, Begon M, Khalil H.   +26 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Safety of Administration of Vasopressors Through Peripheral Compared to Central Venous Catheters in a Rural Kenyan Hospital: Protocol for a Prospective Observational Cohort Study.

JMIR Res Protoc
Gao GH, Kimani B, Lepore L, Aghababa Z, Gitura H, Kinuthia M, Musau J, Muthoki J, Mwonge A, Ndibaru F, Ndubi AV, Ndungu J, Nixon K, Odhiambo M, Okari W, Thairu B, Vihenda L, Wojcik RM, Brotherton BJ, Rudd KE.   +19 more
europepmc   +1 more source

First-in-Human Randomized Controlled Pilot Trial of a Maxillofacial Drug Delivery Platform for Low-Dose Systemic Delivery. [PDF]

Cureus
Ramachandran S, Kandasamy R, Verma K, Ashokan PL, Murugan J, Sudhakar J, Janardhanan HA, Ur A.   +7 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Evidence of the Utility of Needle-Free Injectable Devices for Subcutaneous Administration of Biopharmaceuticals: Comparable Study of in vivo Pharmacological and Vaccination Ability to Normal Injection. [PDF]

Med Devices (Auckl)
Taharabaru T, Kubohira Y, Taniguchi K, Horita T, Higashi T, Motoyama K.   +5 more
europepmc   +1 more source