Results 181 to 190 of about 9,451,716 (342)

VARIABLES OF THE IMAGE OF TOURIST DESTINATION [PDF]

open access: yes
The image of a destination is more than a distinguishing element; it is a component of the supply and brings more value to it. The image of a destination can be the decisive component, while the other elements re relatively alike (1).
Ban Olimpia
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

SUSTAINABLE DEVELOPMENT IN THE GLOBAL ECONOMY [PDF]

open access: yes
The actual paper comes with an approach regarding the sustainable development in today’s world and the global economy. The way of proceeding is the following: the main causes of the current economic crisis are analyzed and it is demonstrated that ...
Drd. Anagnoste Sorin   +1 more
core  

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