mRNA nanodelivery systems: targeting strategies and administration routes [PDF]
Biomaterials Research, 2023 With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention and treatment of various refractory diseases.
Mujie Yuan +6 more
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Administration Routes as Modulators of the Intrahepatic Distribution and Anti-Anemic Activity of Salicylic Acid/Fe3O4 Nanoparticles [PDF]
Biomedicines, 2022 The liver is a key organ in the pharmacokinetics of iron oxide nanoparticles (IONPs). This paper examined how the intravenous (IV) or intragastric (IG) route of administration influenced the intrahepatic distribution or therapeutic effects of IONPs ...
Bogdan Mîndrilă +5 more
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Formulation Strategies of Nanosuspensions for Various Administration Routes [PDF]
Pharmaceutics, 2023 Nanosuspensions (NSs), which are nanosized colloidal particle systems, have recently become one of the most interesting substances in nanopharmaceuticals.
Sıla Gülbağ Pınar +3 more
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Extracellular Vesicles: A Review of Their Therapeutic Potentials, Sources, Biodistribution, and Administration Routes [PDF]
International Journal of NanomedicineXiaorong Su,1,* Hongxiang Wang,2,* Qiubai Li,3,4 Zhichao Chen1 1Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Hematology,
Su X, Wang H, Li Q, Chen Z
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Effect of administration routes on the efficacy of human umbilical cord mesenchymal stem cells in type 2 diabetic rats [PDF]
Frontiers in EndocrinologyBackgroundHuman umbilical cord mesenchymal stem cells (UCMSCs) are being investigated in various clinical trials for different conditions, including type 2 diabetes mellitus (T2DM).
Qiqiang Tao +8 more
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Effect Analysis of Extracellular Vesicles in the Treatment of Bronchopulmonary Dysplasia via Different Drug Delivery and Administration Routes [PDF]
International Journal of NanomedicineWanting Xu,1– 3 Siyu Chen,1– 3 Ting Liang,1– 3 Lan Kang,1– 3 Qinxin Zheng,1– 3 Yan Yang,1– 3 Ling Guo,3 Jing Liu,3 Rong Zhang,1– 3 Wenbin Dong1– 3 1Division of Neonatology, Department of Pediatrics, the Affiliated Hospital of Southwest Medical University,
Xu W +9 more
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Carrier Systems for Advanced Drug Delivery: Improving Drug Solubility/Bioavailability and Administration Routes [PDF]
PharmaceuticsThe disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design of drug delivery systems.
Sonia Losada-Barreiro +4 more
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Advancements in Nanoemulsion-Based Drug Delivery Across Different Administration Routes [PDF]
PharmaceuticsNanoemulsions (NEs) have emerged as effective drug delivery systems over the past few decades due to their multifaceted nature, offering advantages such as enhanced bioavailability, protection of encapsulated compounds, and low toxicity.
Maria D. Chatzidaki, Evgenia Mitsou
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Adverse events in different administration routes of semaglutide: a pharmacovigilance study based on the FDA adverse event reporting system [PDF]
Frontiers in PharmacologyBackgroundWith the continuously increasing incidence of type 2 diabetes, glucagon-like peptide-1 (GLP-1) receptor agonists, known for their dual benefits of effectively controlling blood glucose levels while also reducing weight and lowering ...
Kaibin Niu +4 more
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Routes of administration for adeno-associated viruses carrying gene therapies for brain diseases
Frontiers in Molecular Neuroscience, 2022 Gene therapy is a powerful tool to treat various central nervous system (CNS) diseases ranging from monogenetic diseases to neurodegenerative disorders. Adeno-associated viruses (AAVs) have been widely used as the delivery vehicles for CNS gene therapies
Kai Zhou +6 more
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