Results 91 to 100 of about 643,499 (354)

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Antibody Conjugation and Formulation [PDF]

, 2019
In an era where ultra-high antibody concentrations, high viscosities, low volumes, auto-injectors, and long storage requirements are already complex problems with the current unconjugated monoclonal antibodies on the market the formulation demands for ...
Alves, Nathan J.
core   +1 more source

Intragastric Route of Administration [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Intrapulmonary Route of Administration [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Clinical and pathological changes in goats inoculated Corynebacterium pseudotuberculosis by intradermal, intranasal and oral routes [PDF]

, 2013
This study describes lesions and clinical responses that develop in goats following experimental infection with Corynebacterium pseudotuberculosis by intradermal, intranasal and oral administration.
Abdullah, Faez Firdaus Jesse, Haron, Abdul Wahid, Mohd Nordi, Nur Adza Rina, Saad, Mohd Zamri, Saharee, Abdul Aziz, Shamsudin, Shahirudin   +5 more
core  

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Working Toward Equality, Updated, Race, Employment, and Public Transportation in Erie County [PDF]

, 2017
As documented in the 2016 PPG report, “Working Toward Equality,” there are severe racial disparities in employment and earnings in Erie County. In this report, we update the data from the 2016 report and add new research and analysis about one important ...
Krolikowski, Aaron, Magavern, Sam
core   +1 more source

Patterns of cocaine and opioid co-use and polyroutes of administration among street-based cocaine users in Montréal, Canada [PDF]

, 2013
Background: Effective public health programs aimed at problematic cocaine users are challenged by the fact that they can have complex patterns of drug use with respect to polysubstance use and routes of drug administration.
Richer, Isabelle, Roy, Élise, Vandermeerschen, Jill   +2 more
core   +1 more source