A comparison of the hypoglycemic effect of insulin with systemic venous and portal venous administration [PDF]
, 1963 The hyperglycemic effect of insulin by prolonged intraportal and systemic infusion was measured in unanesthetized dogs with a modified portacaval transposition. There was no significant difference in response with the two routes of administration.
Bell +55 more
core +1 more source
Controlled-release of opioids for improved pain management [PDF]
, 2016 The adequate treatment of pain remains one of the major medical challenges. Morphine and other opioid drugs are most commonly used to counteract moderate to severe pain, but they are also increasingly accessed by patients with chronic non-malignant pain.
Ballet, Steven +5 more
core +1 more source
Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs [PDF]
, 2020 Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Croubels, Siska +6 more
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Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]
, 2012 Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Danish Ahmed +3 more
core +2 more sources
A Compensatory Liability Regime to Promote the Exchange of Microbial Genetic Resources for Research and Benefit Sharing [PDF]
, 2011 Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules ...
Andersen, Hanne +10 more
core +2 more sources
Comparison of Intravenous Dexamethasone versus Perineural Dexamethasone as an Adjuvant to Local Anaesthesia in Supraclavicular Brachial Plexus Block for Upper Limb Surgeries: A Randomised Clinical Study [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Dexamethasone is a potent adjuvant for prolonging analgesia in supraclavicular brachial plexus blocks. However, the optimal route of administration—perineural or intravenous—remains a subject of debate.
Priya Kishnani +4 more
doaj +1 more source
Helminthologia, 2022 Alveolar echinococcosis (AE) caused by the larval stage of Echinococcus multilocularis is serious parasitic diseases associated with the host´s immunosuppression. The effects of human non-immune dialyzable leukocyte extract (DLE) on immune cells in blood
Ciglanová D. +4 more
doaj +1 more source
Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice [PDF]
, 2019 Background With increasing access to legal cannabis across the globe, it is imperative to more closely study its behavioral and physiological effects.
Boehm, Stephen L., II +3 more
core +2 more sources
Trojan Microparticles for Drug Delivery
Pharmaceutics, 2012 During the last decade, the US Food and Drug Administration (FDA) have regulated a wide range of products, (foods, cosmetics, drugs, devices, veterinary, and tobacco) which may utilize micro and nanotechnology or contain nanomaterials.
Thierry F. Vandamme +2 more
doaj +1 more source
Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration under Similar Systemic Exposures [PDF]
, 2019 Objective To test whether an individual's subjective responses to alcohol are similar when the breath alcohol concentration (BrAC) trajectory resulting from oral administration is matched by intravenous administration.
Boes, Julian +6 more
core +1 more source