Results 31 to 40 of about 116,396 (263)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Impact of the built environment on urban mobility patterns and advanced transport dynamics: a systematic review

Transportation Research Interdisciplinary Perspectives
This systematic review explores the complex relationships between the built environment, transport systems, and travel behaviours, synthesising findings from 62 studies screened from the Scopus database.
Saba Ayub, Yuting Hou
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Administrative training and its impact on improving administrative functions to raise the efficiency of employees in the Youth and Sports Directorate of MSila– Algeria- [PDF]

Ziglôbitha
: This study aimed to identify the degree to which administrative training contributes to building and developing the competence of employees in the Youth and Sports Directorate, by improving their administrative inputs represented in administrative ...
Lalem Layachi & Lamara Salim
doaj   +3 more sources

Machine learning assisted multi-objective optimization of a thermal management and barrier integration structure for battery thermal safety

Future Batteries
To ensure both thermal safety and performance in high-energy-density lithium-ion battery systems, this study proposes an integrated modelling and optimization framework for a novel Thermal Management and Barrier Integration Structure (TMBIS), which ...
Yongxi Wu, Anthony Chun Yin Yuen, Xinyan Huang   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Gloss to the Judgement of the Supreme Administrative Court of 2 July 2018 (II OSK 3285/17, LEX No. 2523637)

Studia Iuridica Lublinensia, 2019
The Supreme Administrative Court in the judgement of 2 July 2018 (II OSK 3285/17, LEX No. 2523637) assumed that the decision ordering the removal of the irregularities found in the construction work may be directed to the administrator of this facility ...
Sławomir Zwolak
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

INSTITUTIONAL BUILDING AND ARCHITECTONICS OF POLITICAL AND ADMINISTRATIVE INSTITUTIONS

Вісник Харківського національного університету імені В. Н. Каразіна: Серія "Питання політології", 2021
In the process of modernization, based on the development of the potential of public administration and the growth of social capital, an open type of interaction between the state and society is formed, where institutions act as the necessary conductors ...
Pavlo Bozhko
doaj   +1 more source