Results 41 to 50 of about 1,594,543 (304)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Id. Martonyi János élete és munkássága [The Life and Work of János Martonyi Sr.]

KözigazgatásTudomány
The study presents the life and scientific career of János Martonyi Sen. As a member of the Magyary School, he dealt with administrative law. The first half of his work took place in the civil era of administrative law, the second part in the socialist ...
Gyula Koi
doaj   +1 more source

Well‐being and burnout: One size does not fit all

Journal of the American College of Emergency Physicians Open, 2020
Well‐being and burnout are concepts that have become well described throughout emergency medicine. In the past, both well‐being and burnout have been defined and addressed as a singular phenomenon, similar for all physicians, regardless of career stage ...
Jenny L. Castillo, Bernard P. Chang, Rita A. Manfredi, Jay Kaplan   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

career service papers - csp 17/19

, 2019
Themen dieser Ausgabe sind veränderte Anforderungen an Hochschule und Arbeitgeber*innen (Generation Z), Beiträge zu studentischen Praktika und zur Qualitätssicherung von Praktika, ein Beitrag zur Beschäftigungsfähigkeit und Qualitätssicherung im Rahmen ...
Dorenburg, Christiane, Buchwald, Christine, Schröder, Andrea, Assel, Jessica, Menke, Marcellus, Aufurth, Ludmilla, Balks, Anne-Dörte, Strübel, Lisa, Vedder, Günther, Waldermann, Clara Maria   +9 more
core   +1 more source

The Organizational Justice of the Administrative Leaders and its Impact on Employees' Career Performance

Journal of Economic Development, Environment and People, 2017
. The aim of this study is to help us to know the degree of Organizational Justice practiced by the administrative leaders in Baghdad for Economic Sciences and of Al-Ma'mun privet university colleges in Baghdad and its relationship to the employees' work
Zaid Yaseen Saud Al-Dulaimi
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Maintaining longevity and fulfillment in academic surgery

Trauma Surgery & Acute Care Open
Academic surgery is a demanding and multifaceted career that places sustained pressure on clinical performance, scholarly productivity, administrative service, and personal resilience.
Mayur Narayan, Jamie Coleman, Grace Rozycki, Leah Aakjar, Adrian Park   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Diplomáticos, Unión Europea y MERCOSUR: una primera comparación de los grupos profesionales de la integración en los casos de Argentina y Francia

Cahiers des Amériques Latines, 2014
The different institutional conceptions existing in the MERCOSUR and the European Union imply that administrative actors such as career diplomats in the case of Argentine and France respectively, must consider their career paths taking into account ...
Facundo Solanas
doaj   +1 more source