Results 221 to 230 of about 1,886,233 (353)

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Fall prevention through a systems approach: SEIPS, AcciMap and HTA findings from patient safety specialists. [PDF]

Age Ageing
Fray M, Jun GT, Hignett S.
europepmc   +1 more source

The Field of Administrative Contracts in the Romanian Positive Law Related to the Provisions of Art. 2 Item (1) Let. C) from Law Nr. 554/2004 Regarding the Administrative Legal Dispute

, 2012
Cristian Giuseppe Zaharie, Niculae Gamenţ-Antoniu   +1 more
openalex   +1 more source

Commentaries on reneual model rules on EU administrative procedure (Book IV – contracts; chapter 3 – execution and validity of EU contracts) [PDF]

, 2017
György Péter Szilvásy
openalex  

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

The role and challenges of clinical research coordinators: insights from a national survey. [PDF]

BMC Med Res Methodol
Cagnazzo C, Testoni S, Speranza D, Mannozzi F, Stabile S, Federici I, Betti M, Ferrari A, Penolazzi L, Franchina V.   +9 more
europepmc   +1 more source

The distinction of the administrative contract from other types of contracts

, 2011
Liana-Teodora Pascariu
openalex   +1 more source

Administrative Contract as a Substitute for an Administrative Act in the Resolution of Administrative Matters

Merima Tanović, Amra Jašarbegović, Aldin Jelovac   +2 more
openalex   +2 more sources

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Burden of Mental and Behavioral Disorders in Colombia, 2022: A Subnational Analysis Based on Disability-Adjusted Life Years. [PDF]

Int J Environ Res Public Health
Quintero Díaz KJ, Gutierrez Lesmes OA, Salamanca Ramos E.   +2 more
europepmc   +1 more source