Results 111 to 120 of about 1,747,414 (281)

Cancer Surveillance using Data Warehousing, Data Mining, and Decision Support Systems [PDF]

open access: yes, 2000
This article discusses how data warehousing, data mining, and decision support systems can reduce the national cancer burden or the oral complications of cancer therapies, especially as related to oral and pharyngeal cancers.
Adya, Monica   +2 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Správní žaloba ve veřejném zájmu [PDF]

open access: yes, 2013
Text se zabývá oprávněním nejvyššího státního zástupce podat ke správnímu soudu žalobu proti rozhodnutí správního úřadu ve veřejném zájmu.The text deals with the authority of the supreme public prosecutor to bring a legal action against a decision of an ...
Koudelka Zdeněk
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

The Efficiency of Decentralised and Devolved Government: A Framework [PDF]

open access: yes
A wide range of geographically decentralised governance structures exists across countries (Ter-Minassian, 1997). These differences in administrative and constitutional mechanisms come about, at least partly, by historical accident and wider political ...
Alex Christie, Kim Swales
core  

\u3ci\u3eChevron\u3c/i\u3e Without the Courts? The Supreme Court\u27s Recent \u3cem\u3eChevron\u3c/em\u3e Jurisprudence Through an Immigration Lens [PDF]

open access: yes, 2012
The limits of administrative law are undergoing a seismic shift in the immigration arena. Chevron divides interpretive and decision-making authority between the federal courts and agencies in each of two steps.
Rana, Shruti
core   +1 more source

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