Results 21 to 30 of about 5,709,188 (328)

Automated, administrative decision‐making and good governance: Synergies, trade‐offs, and limits

PAR. Public Administration Review
Automated, administrative decision‐making (AADM) is a key component in digital government reforms. It represents an aspiration for a better and more efficient administration but also presents challenges to values of public administration.
Ulrik B. U. Roehl, Morten Balle Hansen
semanticscholar   +1 more source

The Schorsing in Implementation of Administrative Decision that Endanger the Environment by Administrative Court

, 2018
The postponement criteria of the implementation of KTUN (Administrative Court Decision) based on Article 67 of the Act Number 5, 1986 concerning the State Administrative Court (the Act of Administrative Court) merely states that such Postponement can be ...
Miftah Sa'ad Caniago
semanticscholar   +1 more source

Administrative law and the machines of government: judicial review of automated public-sector decision-making

Legal Studies, 2019
The future is likely to see an increase in the public-sector use of automated decision-making systems which employ machine learning techniques. However, there is no clear understanding of how English administrative law will apply to this kind of decision-
Jennifer Cobbe
semanticscholar   +1 more source

Algorithm-assisted decision-making in the public sector: framing the issues using administrative law rules governing discretionary power

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2018
This article considers some of the risks and challenges raised by the use of algorithm-assisted decision-making and predictive tools by the public sector.
M. Oswald
semanticscholar   +1 more source

Shadow writing and participant observation : a study of criminal justice social work around sentencing [PDF]

, 2008
The study of decision-making by public officials in administrative settings has been a mainstay of law and society scholarship for decades. The methodological challenges posed by this research agenda are well understood: how can socio-legal researchers ...
Burns, Nicola, Halliday, Simon, Hutton, Neil, McNeil, F., Tata, Cyrus   +4 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source