Results 71 to 80 of about 247,466 (256)
Tax Control Between Legality and Motivation: A Case Study on Romanian Legislation
LawsOur study aims to evaluate the current Romanian context for tax control by correlating the legal framework with the administrative model, as derived through empirical analysis.
Ioana Maria Costea +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Studia Prawa PublicznegoThe registration requirement is the basis for keeping population records in Poland. One element concerns the obligation to register at the place of permanent or temporary residence.
Maciej Jurzyński
doaj +1 more source
" الرقابة القضائية على القرار الإداري المتصل بالعملية الانتخابية". [PDF]
مجلة البحوث القانونية و الاقتصاديةلا شك أن الحياة تتطور بشكل دائم ومستمر، ومن ثَم فإن كل ما هو موجود ويطبق في الدنيا لا بد وأن يتجدد وتطور الحياة ومنها النظم القانونية التي تتناول تنظيم هذه الحالة، ومن تلك النظم القانونية العملية الانتخابية؛ إذ تعد الوسيلة الديقراطية في اختيار الشعب ...
يوسف مفلح مبارك عيد مرشد الوسمي
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Planning annuity (fee). Civil and tax law regulations
Journal of Modern ScienceAdopting a new or changing the existing local development plan is most often associated with an increase in the value of real estate. When selling the property, the owner of the property is obliged to pay a special fee (planning rent) in connection with ...
Dagny Derewiecka +2 more
doaj +1 more source