Results 151 to 160 of about 166,663 (295)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Administrative Law and Practice (3rd Edition)

, 2010
In Administrative Law and Practice a former FTC attorney provides advice, techniques, and tips on the procedures necessary for engaging federal and state agencies in all avenues of regulated conduct. This might involve judicial review of agency decisions
Koch, Charles H, Murphy, Richard
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Striking a Balance: Centralised and Decentralised Decisions in Government [PDF]

This paper identifies factors to be looked at when considering the extent to which decisions within government should be centralised or decentralised.
Natalie Brady
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Access to essential medicines for mothers and children: regulatory challenges and gender justice. [PDF]

J Pharm Policy Pract
Natalis A, Jalil A.
europepmc   +1 more source

Review of Final Administrative Decisions by Administrative Authorities

, 2012
V diplomové práci jsem se zabývala přezkoumáváním pravomocných správních rozhodnutí správními orgány. V prvních dvou kapitolách jsem se zaměřila na obecné pojetí přezkoumávání správních rozhodnutí správními orgány a na stručný vývoj právní úpravy na ...
Vybíralová, Michaela
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Governing autonomous AI in clinical care: the window is narrowing. [PDF]

Health Aff Sch
Eisenberg KW, Patel KK.
europepmc   +1 more source

ACCOUNTING AND ANALYTICAL ENSURING ADMINISTRATION OF ADMINISTRATIVE DECISIONS

The article is devoted to the study of the issue of accounting and analytical supportfor management decision-making. The article defines the importance of the formation of effectivesystems of accounting, management accounting and analysis, as well as the interrelationshipsbetween them, which will contribute to increasing the effectiveness of accounting
openaire   +2 more sources