Results 131 to 140 of about 391,997 (324)

Probability of pharmacokinetic/pharmacodynamic target attainment for different piperacillin/tazobactam dosing regimens in renally impaired patients in a non‐intensive care unit setting

British Journal of Clinical Pharmacology, EarlyView.
Aims To optimize antibiotic therapy for pathogens classified as susceptible, increased exposure (I), an increased exposure of piperacillin/tazobactam (PTZ) is required. However, dosing recommendations are currently only available for patients with normal renal function.
Emma Dohmann, Stefan Hagel, Max Kurlbaum, Paul Schellong, Oliver Scherf‐Clavel, Güzin Surat   +5 more
wiley   +1 more source

Zastosowanie przepisów działu IVa kodeksu postępowania administracyjnego w sprawach kończących się wydaniem decyzji związanej

Studia Administracyjne
The subject of research and analysis undertaken within the framework of this study is the issue of the possibility of applying the provisions of Section IVa of the Code of Administrative Procedure in a situation in which a provision of a substantive law ...
Małgorzata Biszczanik
doaj   +1 more source

IMPLEMENTATION OF THE JUDGE’S DISCRETION DURING THE CONSIDERATION OF CASES IN ADMINISTRATIVE PROCEEDINGS: A DOMESTIC ASPECT

, 2022
M. Kharchenko
openalex   +1 more source

Medication adherence during the run‐in phase of clinical trials: A systematic review of methodological and reporting rigour

British Journal of Clinical Pharmacology, EarlyView.
Aims Trial run‐in phases are sometimes used to select adherent participants as a strategy to enrich trials, but the methods employed lack clear regulatory guidance and there are concerns about the transparency of reporting. This review aims to characterize the methods used for adherence measurement and public reporting of run‐in studies.
Non Davies, Bernard Vrijens, Daniel F. B. Wright, Dyfrig A. Hughes   +3 more
wiley   +1 more source

Discuții privind posibilitatea anulării unui act administrativ pe motiv de inoportunitate

Revista Transilvană de Ştiinţe Administrative, 2004
The article discusses the possibility of annulment of an administrative decision enacted with discretion power by the administrative authority, in the light of the Constitution revisited in 2003.
Dacian Cosmin DRAGOŞ
doaj  

Effect of vepdegestrant, a PROTAC oestrogen receptor degrader, on dabigatran and rosuvastatin pharmacokinetics in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims To evaluate the effects of vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) oestrogen receptor degrader, on the pharmacokinetics of dabigatran (a P‐glycoprotein [P‐gp] substrate) and rosuvastatin (a breast cancer resistance protein [BCRP] substrate).
Derek Z. Yang, Li Zhou, Jennifer A. Winton, Kyle T. Matschke, Constantino Kantaridis, Kristine Doyle, Kimberly C. Lee, Naihan Chen, Yuanyuan Zhang, Weiwei Tan   +9 more
wiley   +1 more source

PROBLEMS OF LAW ENFORCEMENT DISCRETION IN ADMINISTRATIVE PROCEEDINGS

, 2023
T.V. Mikhailina, Ya.M. Ivanchenko
openalex   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Legislative Delegation and Two Conceptions of the Legislative Power [PDF]

, 2006
[Excerpt] The current federal government, with its burgeoning administrative agencies, does not embody what most Americans would recognize as the constitutional doctrine of separation of powers.
Sarvis, Robert C.
core   +1 more source