Results 61 to 70 of about 6,189 (257)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Administrative dispute and the administrative adjudication process in contemporary serbia -some problems of reform and amendment directions-

Zbornik Radova Pravnog Fakulteta u Splitu, 2010
The subject of this paper is the functioning of one part of the new judicial system in Serbia put in place by judicial law in 2008, and based on the Serbian Constitution of 2006. It deals with the administrative judiciary, i.e. administrative dispute and
Zoran R. Tomić
doaj  

Insurance claim in administrative disputes resolution

Austrian Journal of Humanities and Social Sciences, 2016
To write an article about the institution of insurance claim litigation in administrative judgment, we must also tackle a comparative overview regarding the provision of the claim in the trial of civil cases, harmonized with unifying judicial practice. To have a broader approach, we can not simply refer to any specific provisions of law (No.
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

ADMINISTRATIVE DISPUTE RESOLUTION AND ADMINISTRATIVE COURT PRACTICE OF THE REPUBLIC OF CROATIA

Zbornik Radova Pravnog Fakulteta u Splitu, 2008
In this paper the author reports on the problem areas of administrative dispute resolution which in the Republic of Croatia is regulated by the Administrative Dispute Resolution Act.
Ljiljana Karlovčan-Đurović
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Uniform Interpretation and Application of Law and the Uniqueness of Court Practice in Administrative Adjudication Process

Zbornik Radova Pravnog Fakulteta u Splitu, 2012
The aim of this paper is to analyse what effect on the uniform interpretation and application of administrative law in Croatia, its consequence and the uniqueness of administrative legal practice will have on the new Administration Dispute Act.
Damir Aviani, Dario Đerđa
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O potrzebie alternatyw dla sądowego rozstrzygania sporów pomiędzy władzami administracyjnymi a podmiotami prywatnymi w świetle Zalecenia Komitetu Rady Ministrów R (2001)9

Studia Prawa Publicznego, 2018
The aim of the article is to explain the reasons for the introduction of mediation in administrative law. Mediation is presented in the light of the Recommendation of the Committee of the Council of Ministers R (2001)9 of 5 September 2001 on ...
Bartłomiej Chludziński
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Obligation and implementation of decisions in administrative dispute resolution

Zbornik Radova Pravnog Fakulteta u Splitu, 2012
In this paper the problem area of obligation and implementation of decisions reached in administrative dispute resolution is analysed. In the introductory part of the paper the importance of the concept of obligation of court decisions for an effective ...
Marko Šikić
doaj