Results 71 to 80 of about 788,725 (322)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Dilemmas in the application of the new law on administrative dispute resolution

open access: yesZbornik Radova Pravnog Fakulteta u Splitu, 2013
This paper points out a few dilemmas and open questions which have arisen over the short application of the new Administrative Dispute Resolution Act. Firstly, the question of the wellfoundedness of the Administrative Dispute Resolution Act’s provisions ...
Lidija Rostaš-Beroš
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Administrative dispute and the administrative adjudication process in contemporary serbia -some problems of reform and amendment directions-

open access: yesZbornik Radova Pravnog Fakulteta u Splitu, 2010
The subject of this paper is the functioning of one part of the new judicial system in Serbia put in place by judicial law in 2008, and based on the Serbian Constitution of 2006. It deals with the administrative judiciary, i.e. administrative dispute and
Zoran R. Tomić
doaj  

Insurance claim in administrative disputes resolution

open access: yesAustrian Journal of Humanities and Social Sciences, 2016
To write an article about the institution of insurance claim litigation in administrative judgment, we must also tackle a comparative overview regarding the provision of the claim in the trial of civil cases, harmonized with unifying judicial practice. To have a broader approach, we can not simply refer to any specific provisions of law (No.
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

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