Results 201 to 210 of about 27,411 (263)

Embrace the tension: a decolonial reframing of Implementation Science. [PDF]

BMJ Glob Health
Mascayano F, Rivera E, Montenegro C, Bass JK.   +3 more
europepmc   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Translational framework for implementation evaluation and research: a critical approach to patient-centred equity design. [PDF]

Implement Sci Commun
May CR, Hillis A, Gravenhorst K, Bradley CD, Geng E, Boehmer K, Gallacher KI, Chew-Graham CA, Lippiett K, May CM, Smyth R, Nolte E, Stevenson F, Richardson A, Mair F, MacFarlane A, Montori VM.   +16 more
europepmc   +1 more source

Mapping Charge Interactions in Intrinsically Disordered Proteins

Advanced Science, EarlyView.
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips, Andrea Holla, Magdalena Wojtas, Aritra Chowdhury, Andrea Sottini, Sebastian L. B. König, Natalie Mutter, Nick Lamb, Jonathan Huihui, Monika Lopko, Andrea Soranno, Daniel Nettels, Andrzej Ożyhar, Benjamin Schuler, Kingshuk Ghosh   +14 more
wiley   +1 more source

Self-harm before and during imprisonment: cohort study of males in prison linking population-based routinely collected data in Wales. [PDF]

BJPsych Open
DelPozo-Banos M, Atkinson MD, Lee SC, John A.   +3 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Foster Care and Child Maltreatment Mortality Rates in the US.

JAMA Netw Open
Edwards F, Fong K, Apel R.
europepmc   +1 more source

Reforming nursing reimbursement: direct payment models under Iran's Nursing Service Act in a global context. [PDF]

Cost Eff Resour Alloc
Hatefimoadab N, Jaghargh MT, Abbaszadeh A, Sharafi S, Kianian T, Rezaiye M, Ebadi A.   +6 more
europepmc   +1 more source

Characterising firearm-related databases across Canada: opportunities for data linkage to inform understanding of injury burden and prevention. [PDF]

Int J Popul Data Sci
Karanikas A, Gomez D, Raveendran T, Saunders N.   +3 more
europepmc   +1 more source

"Remember, we don't have race categories here": contradictions and reflections on racism, environment, and health from an interview study among Black German researchers, educators, and care providers. [PDF]

Front Public Health
Payne-Sturges DC.
europepmc   +1 more source