Results 241 to 250 of about 854,128 (308)

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Abortion providers as human rights defenders: policy priorities for South Africa. [PDF]

Front Reprod Health
Khofi L, Rucell J, Matandela M.
europepmc   +1 more source

Small Things like Reasons are Put in a Jar: Reason and Legitimacy in the Administrative State [PDF]

, 2001
Mashaw, Jeffrey L.
core   +1 more source

Statutory regulation in somatology: a public health, professional, and decolonial imperative in South Africa. [PDF]

Front Public Health
Mpofana N, Paulse M, Borg D, Tshabalala SM, Fungisani J, Makgobole MU, Thomas M.   +6 more
europepmc   +1 more source

Impacts of Plant Protection Products on Biodiversity: Limits of Risk Assessment and Avenues to Ground Liability. [PDF]

Risk Anal
Leenhardt S, Mamy L, Barthélémy C, Berny P, Bureau-Point E, Corio-Costet MF, Pesce S, Doussan I.   +7 more
europepmc   +1 more source

Justice and responsibility in climate change adaptation research. [PDF]

Bull World Health Organ
Ferguson K, Atuire CA, McDermid SS, Vedanthan R.   +3 more
europepmc   +1 more source

Evaluating the association of transferring governance of correctional health care services with overdose and all-cause mortality: a retrospective cohort study in British Columbia, Canada. [PDF]

Health Justice
McQuarrie L, Dasgupta D, Nicholls T, Martin RE, McLeod KE, Kinner S, Greiner L, Olley M, Roth K, Palis H, Krishnamoorthy A, Slaunwhite A.   +11 more
europepmc   +1 more source