Results 221 to 230 of about 4,769,243 (370)

7‐Ketodeoxycholic Acid Promotes Colonic Mucosal Healing by Inducing Calcium Release from Endoplasmic Reticulum via the TGR5‐IP3R Pathway

open access: yesAdvanced Science, EarlyView.
7‐KDCA functions by driving intestinal epithelial cell migration through induction of calcium release from the endoplasmic reticulum. The findings emphasize a previously unrecognized property of 7‐KDCA in regulating cell migration, a required process for effective epithelial restitution and repair that is particularly critical for patients with UC to ...
Jing Zhang   +9 more
wiley   +1 more source

AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
A multi‐agent AI (AI co‐scientist) is used to repurpose drugs for liver fibrosis treatment and to guide their experimental characterization. The anti‐fibrotic efficacy and toxicity of these drugs is assessed in multi‐lineage human hepatic organoids grown in microwells (microHOs).
Yuan Guan   +20 more
wiley   +1 more source

Mechanism‐Aware Digital Twin for High‐Temperature Creep Prediction in Mo–Re Alloys

open access: yesAdvanced Science, EarlyView.
A digital twin framework enables real‐time monitoring of creep in refractory alloys and reveals dislocation‐drag‐induced Re segregation to grain boundaries. Inspired by this, La2O3 dispersion is introduced to suppress dislocation motion — concurrently mitigating Re segregation and enhancing creep resistance.
Jinhan Xu   +7 more
wiley   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

open access: yesAdvanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao   +4 more
wiley   +1 more source

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