Results 241 to 250 of about 4,769,243 (370)

Deep Learning‐Powered Nanoplasmonic Biosensing Approach Enables Ultrasensitive Extracellular Vesicles Profiling for Cancer Screening

open access: yesAdvanced Science, EarlyView.
This study presents a Kolmogorov–Arnold network (KAN)‐powered nanoplasmonic biosensing platform for ultrasensitive detection of small extracellular vesicles in serum, enabling highly accurate pancreatic cancer screening. The method achieves an area under the curve (AUC) of 0.99 in a large clinical cohort, offering a robust and interpretable deep ...
Jiaheng Zhu   +21 more
wiley   +1 more source

A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration

open access: yesAdvanced Science, EarlyView.
Herein, guanidinium‐modified calix[5]arene (GC5AY) is developed featuring small size, positive charge, and desirable amphiphilicity, that can efficiently traverse the nasal mucosal barrier for brain drug delivery. Additionally, possessing inherent therapeutic functions, GC5AY can thus serve as a single‐molecule pleuripotent scaffold for multi‐target ...
Jian‐Mei Gao   +11 more
wiley   +1 more source

On the Design of Effective Water‐Soluble Actinide‐Masking Ligands Through Ligand Structure Modulation

open access: yesAdvanced Science, EarlyView.
Ligand topology and non‐coordination atoms are proved to be important for the design of effective water‐soluble actinide masking agents. Abstract Water‐soluble actinide‐masking ligands are fundamentally important for achieving efficient lanthanide/actinide separation and for the development of water‐soluble f‐block complexes for bioimaging and ...
Bin Li   +9 more
wiley   +1 more source

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