Results 41 to 50 of about 230,255 (360)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock, Jin Nakahara, Becky Parks, Kerstin Allen, Sami Fam   +4 more
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Protection of Consumers’ Rights in Railwayin the Slovak Republic [PDF]

Yearbook of Antitrust and Regulatory Studies, 2017
The paper focuses on railway services in the Slovak Republic and describes the organization of public administration in this area and its responsibility for protecting consumer rights.
Matej Horvat, Hana Magurová, Mária Srebalová   +2 more
doaj   +1 more source

The Conflict of Legal Permission of Crime against the Unprotected Outlaw (Mahdūr al-Dam) with the Teachings of Islamic Jurisprudence

مطالعات تطبیقی فقه و اصول مذاهب, 2023
According to Article 302 of the Islamic Penal Code of Iran (April 21, 2013), if someone commits an offence against an unprotected outlaw (mahdūr al-dam) and someone who deserves death, she/he is exempted from retaliation (qiṣᾱṣ) and paying blood money ...
Naser Ghasemi , Towhid Hajipour
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Preventing Maladministration on Issuing Mining License (a Case Study in Southeast Sulawesi, Indonesia)

SHS Web of Conferences, 2018
This study is aimed at exploring appropriate method in embodying and applying the principle of good governance in managing strategic resources, i.e. in issuing mining license.
Haris Oheo K., Muchtasar Rizal, Sahbudin
doaj   +1 more source

A Comparative Study of Marriage of the Adopter with the Adopted Child in Islam, Law of Iran and French Law [PDF]

پژوهش تطبیقی حقوق اسلام و غرب, 2019
One of the important issues of adoption institute is supervisor’s marriage with adopted person. Although this subject is predicted in new Law on the Protection of Unsupervised and Bad-supervised Teens enacted in 2013, because of the silence of its ...
MohammadSadegh Tabatabaei, Hamed Heidari Irani, Nafiseh Jafari   +2 more
doaj   +1 more source

Teaching Global Administrative Law

, 2023
In the last 40 years, many public functions, traditionally exercised by national authorities have been governed by global bodies and organizations. These bodies are different from the traditional International Organizations (IOs) because of their memberships, their mission, their regulatory powers, and the tools at their disposal.
openaire   +2 more sources