Results 51 to 60 of about 1,786,784 (271)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

open access: yesAdvanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat   +11 more
wiley   +1 more source

Market abuse [PDF]

open access: yes, 2002
On 1st December 2001, the Financial Services and Markets Act 2000 (‘FSMA’) came into force. One of its most controversial sections is Part VIII which gives the Financial Services Authority (‘FSA’) the power to impose civil penalties for market abuse ...
Alcock, A
core  

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng   +16 more
wiley   +1 more source

The problems of petty deeds in criminal law

open access: yesЮридический вестник Самарского университета
The issues of legality of regulation of minor crimes in criminal legislation are considered. This takes into account the presence in the administrative legislation of offenses containing the word “minor” in the name.
E. V. Blagov
doaj   +1 more source

ADMINISTRATIVE CONTRACTS IN THE CONTEXT OF THE NEW CIVIL CODE AND THE NEW CIVIL PROCEDURE CODE [PDF]

open access: yesChallenges of the Knowledge Society, 2019
The Romanian law concerning administrative contracts has evolved greatly in the last three decades; the New Civil Code, which came into effect in 2009, and the New Civil Procedure Code, which came into effect in 2010, have important stipulations in the
Crina Alina DE SMET
doaj  

Using knowledge based micro simulation in analysing the application of legislation [PDF]

open access: yes, 1993
The method of knowledge based micro simulation (KBMS) was developed to help determine (ex-ante) the socio-economic consequences of social security legislation.
Svensson, J.S.
core   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

open access: yesAdvanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec   +5 more
wiley   +1 more source

New approaches to the right to be heard in relation to the application of alternatives to administrative sanctions

open access: yesCentral European Public Administration Review, 2018
The right to be heard is one of the key instruments that ensure adequate protection of the  participants´ rights during the proceedings before the administrative authority.
Soňa Skulová, Radislav Bražina
doaj   +1 more source

Legislative Reform on Administrative Responsibility

open access: yesSiberian Law Review, 2020
Draft laws introducing significant changes to the institution of administrative responsibility have significant shortcomings. They only declare their connection with the previously published Concept of the new Code of the Russian Federation on Administrative Offenses.
Yu. P. Shevchenko, I. A. Kositsin
openaire   +3 more sources

The Legislative History of the Administrative Procedure Act [PDF]

open access: yes, 2016
During the twentieth century, one of the most important developments in American government and politics was the expanding power of administrative agencies of all kinds.
Elias, Roni
core   +2 more sources

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