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环境与职业医学, 2022 BackgroundBy analyzing the publication of scientific and technological papers of the provincial centers for disease control and prevention (CDCs) in China, we can understand their scientific research strength, dominant disciplines, research hotspots, and
Jiao CHEN +3 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
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Universitas Humanística, 2015 The battle of papers: Notes on the Tensions between Written Procedures and Memory in the Agrarian Regularization of Quilombo Lands in Brazil Abstract This article is a reflection on the processes of land regularization enacted by the section 68 of the ...
Cristian J. Salaini +1 more
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
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Baltic Journal of Economic Studies, 2018 The innovation of conceptual provisions of the administrative law doctrine that are based on the priority of rights, freedoms, legitimate interests of an individual, service orientation of the public administration authorities’ performance affects the ...
Olha Tylchyk +2 more
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Constitutional Law: Prison “No-Assistance” Regulations and the Jailhouse Lawyer [PDF]
, 1968 The increasing popularity of the writ of habeas corpus, coupled with the inability of many prison inmates to effectively draft their own habeas petitions, has resulted in the emergence of a group of knowledgeable inmate practitioners willing to assist ...
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Assertive modesty: an economics of intangibles [PDF]
, 1994 At the center of our Symposium stand two papers: A Manifesto Concerning the Legal Protection of Computer Programs (Manifesto) and Legal Hybrids: Between the Patent and Copyright Paradigms (Legal Hybrids). Both are stimulating. Both are lengthy.
Gordon, Wendy J.
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
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Measuring the capability to raise revenue process and output dimensions and their application to the Zambia revenue authority [PDF]
, 2006 The worldwide diffusion of the good governance agenda and new public management has triggered a renewed focus on state capability and, more specifically, on the capability to raise revenue in developing countries.
Alex Radian +76 more
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
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