Results 101 to 110 of about 2,865,726 (296)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Utah Administrative Code 1989, Volume 2
, 1989 Series 83623 | Utah Division of Administrative Rules | Utah Administrative Code | Utah Administrative Code 1989, Volume 2The Utah Administrative Code is the authorized compilation of the administrative law of Utah (See Utah Code Section 63-46a-16 (1987 ...
Utah Division of Administrative Rules
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Procedural rights in composite administrative procedures
, 2020 The two contributions in this legal working paper discuss the various aspects of composite administrative procedures in the context of both Single Supervisory Mechanism (SSM) and Single Resolution Mechanism (SRM) decision-making procedures. It addresses the definition of such procedures, their relevance in the SSM and SRM context, the allocation of ...
Eckes, C., D’Ambrosio, R.
openaire +2 more sources
Other title: DAS-ITS-700-03 Encrypted USB Drive Standard
, 2020 [2020 update]; At head of title: DAS Standard; "EFFECTIVE DATE: 06/28/2017.;" "Revision history: 06/28/2017, original standard; 12/04/2018, updated the exception request language to align with the current procedure; 05/27/2020, Updated standard template ...
Ohio. Department of Administrative Services
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Appeal in administrative procedure
U uvodu ovoga rada su definirani i objašnjeni pojmovi koji su ključni za razumijevanje žalbe u upravnom postupku. Nakon uvodnog upoznavanja s terminologijom i materijom rada, detaljno su analizirani članci Zakona o općem upravnom postupku koji se odnose ...
Gebert, Josip
core +2 more sources
PARTIES IN THE ADMINISTRATIVE PROCEDURE
, 2015 Upravni postupak predstavlja skup procesnih pravila koja određuju način djelovanja javne uprave kada ona odlučuje o pravima i obvezama pojedinih subjekata u tzv. upravnim stvarima, odnosno kada donosi upravni akt.
Trlin, Ivana
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source