Results 71 to 80 of about 194,002 (294)
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
International Reflections on Administrative Procedure: OECD and Council of Europe
Since the 90s, two intergovernmental organizations, the Organization for Economic Cooperation and Development (Oecd) and the Council of Europe, started publishing recommendations concerning national administrative procedures.
DE BELLIS, M, De Bellis, M.
core
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Pluralistic Value and Administrative Procedure
(1)行政程序之意義:行政程序之觀念之形成,大陸法系國家遠比英美法系國家為晚,此與大陸法系國家過度重視實體規範價值而輕視程序價值規範之法思想與法文化‧法意識,不無關係。今日,已具有行政程序法(即將行政程序實定法化)之多數國家中,在立法政策上雖有採一般法、統一法及個別法、個別行政領域法之不同立法例,行政程序法之適用範圍,廣範者甚至包括事後行政程序等,其界定亦非一致,但其理念均係來自於英國「自然正義」(Natural justice)與美國「正當程序」(Due process of law)法理,則無異見。(
蔡秀卿; Tsay, Shiow-Ching
core
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Appeal in administrative procedure
U uvodu ovoga rada su definirani i objašnjeni pojmovi koji su ključni za razumijevanje žalbe u upravnom postupku. Nakon uvodnog upoznavanja s terminologijom i materijom rada, detaljno su analizirani članci Zakona o općem upravnom postupku koji se odnose ...
Gebert, Josip
core +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source

