Results 91 to 100 of about 13,105 (295)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Efficiency and standard of proof in procedures that impose administrative sanctions

, 2022
This article addresses the administrative procedures from Law and Economics perspective. In this sense, this work examines the mentions to efficiency, efficacy, and procedural economy, in Chilean administrative law, by holding that those concepts must be
Wenzel, Adolfo Weber, Jiménez Valenzuela, Claudio, Delgado, Nicolas Carrasco, Adolfo Weber Wenzel, Weber Wenzel, Adolfo, Carrasco Delgado, Nicolás, Valenzuela, Claudio Jimenez, Claudio Jiménez Valenzuela, Nicolás Carrasco Delgado   +8 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The evolution of regulation through administrative and criminal sanctions

, 2021
La plupart des pays occidentaux ont multiplié les sanctions administratives depuis la Première Guerre mondiale pour pallier les carences de la répression pénale.
Belle, Sandrine
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sanctions for administrative delicts and protective measures

, 2016
This thesis deals with sanctions and protective measures. The thesis primarily discusses types of sanctions and protective measures that may be imposed for administrative delicts; it also addresses circumstances to be considered in imposing sanctions ...
Moravec, Ondřej
core  

Redesigning the Concept of Law Enforcement in Administrative Violations of General Elections in Indonesia

Yuridika
Trial mechanism as the only procedure in resolving election administrative violations is a mechanism that is not in accordance with the concept of law enforcement in administrative law that uses not only the trial mechanism but also direct sanctions ...
Jamil Jamil, Moh. Fadli, Shinta Hadiyantina, Ngesti Dwi Prasetyo   +3 more
doaj   +1 more source

Maciej Bernatt, Sankcje administracyjne: między efektywnością i proceduralną sprawiedliwością

Studia Prawa Publicznego, 2019
Maciej Bernatt, Administrative Sanctions: Between Effi ciency and Procedural Fairness (Sankcje administracyjne: między efektywnością i proceduralną sprawiedliwością), „Review of European Administrative Law” 2016, vol. 9, iss. 1, s.
Lucyna Staniszewska
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sanctions and protective measures regarding administrative infractions

, 2016
The aim of the thesis is to provide an overview of sanctions and measures of pro- tection which can be imposed as a result of administrative offences according to the Czech Act on Administrative Offences and attempt to answer some of the questi- ons ...
Geuss, Hana
core