Results 111 to 120 of about 1,318,118 (307)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Transylvanian Review of Administrative Sciences, 2008 The paper aims a comparative analysis of curricula for Bachelor studies in the area of administrative sciences. The objectives of research focused on elaboration of a set of indicators, based on the curricular contents of the programmes from the first ...
Lucica MATE
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THE EVALUATION OF EDUCATIONAL SERVICES QUALITY BY THE STUDENTS OF THE FACULTY OF ECONOMICAL SCIENCES "DIMITRIE CANTEMIR" CLUJ-NAPOCA [PDF]
The evaluation of the educational services quality by the students represents an important element of the internal quality monitoring process for the identification of the necessary actions required in the continuous improvement of the offered ...
Rusu Corina, Vlad Miranda-Petronella
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Analysis Of Factors Influencing Student Learning Achievement [PDF]
, 2018 This study aims to determine the influence of internal and external factors on the level of student achievement in Education Program Administration Office Faculty of Social Sciences Makassar State University.
Akib, Haedar +3 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Spectrum, volume 24, number 02 [PDF]
, 1997 Manuel Pacheco chosen to lead UM -- HMO consultant hired for Health Sciences Center -- Board supports proposed Challenge Scholarships -- UM plans for mission enhancement -- Armon Yanders reappointed to U.S.
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A conceptual model for EAI adoption in an e-government environment [PDF]
, 2006 The non-integrated nature of Local Government Authority (LGA) Information Systems (IS) is strongly associated with the inconsistency and duplication of data, reduction in data integrity and quality, and high operational and maintenance cost. The reason
Kamal, M, Themistocleous, M
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