Results 121 to 130 of about 3,347,283 (277)

Administrative Practice [PDF]

open access: yesAmerican Journal of Public Health and the Nations Health, 1943
openaire   +2 more sources

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang   +12 more
wiley   +1 more source

An Analysis of Graduate Medical Education Program Coordinator Job Descriptions. [PDF]

open access: yesJ Grad Med Educ
Anderson L   +5 more
europepmc   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

open access: yesAdvanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo   +10 more
wiley   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

open access: yesAdvanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang   +11 more
wiley   +1 more source

A mixed methods analysis of clinics' perspectives on community factors influencing access to medications for opioid use disorder. [PDF]

open access: yesAddict Sci Clin Pract
Jaros S   +6 more
europepmc   +1 more source

High‐Resolution Multispectral Photovoltaic Imagers from Visible to Short‐Wave Infrared

open access: yesAdvanced Science, EarlyView.
We demonstrate a monolithic quad‐spectral imager that seamlessly integrates visible and short‐wave infrared detection on a single chip. Through direct photopatterning of an all‐polymer bulk heterojunction and colloidal quantum dots, the device achieves high‐resolution (640 × 512) imaging across 350–2400 nm, enabling multispectral capture for ...
Wanqing Li   +12 more
wiley   +1 more source

HOSPITAL ADMINISTRATION [PDF]

open access: yesAJN, American Journal of Nursing, 1923
openaire   +1 more source

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