Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao +13 more
wiley +1 more source
Staff Perspectives on Implementation of Long-Acting Injectable Preexposure Prophylaxis at a Low-Barrier Syringe Services Program in Philadelphia, PA. [PDF]
Plesons M +7 more
europepmc +1 more source
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang +13 more
wiley +1 more source
Dual‐Responsive Yarn‐Based Artificial Muscles for Adaptive Thermal Management
Inspired by the conscious movements of skeletal muscle, a novel hybrid yarn‐based artificial muscle (HYAM) coupling moisture actuation with controllable recovery is developed. This unique design increases actuation stroke by 128% and shortens recovery time by 91%. This unique design enhances the actuation stroke by 128% and reduces the recovery time by
Mengjiao Pan +11 more
wiley +1 more source
Exploring factors that contribute to the successful implementation of Schwartz Rounds in higher education institutions. [PDF]
Beck S, Taylor C, Maben J.
europepmc +1 more source
BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression
BZW1 attenuates ferroptosis by competitively binding NCOA4 and suppress ferrtinophagy‐mediated iron release. The depletion of BZW1 triggers lipid peroxidation through iron homeostasis. Extracellularly, BZW1 attenuates immunogenic cell death and reinvigorates cytotoxic T‐cell responses.
Linyao Zhao +9 more
wiley +1 more source
Community partners identified implementation considerations prior to a randomized clinical trial for uncontrolled asthma in Federally Qualified Health Centers. [PDF]
George M +12 more
europepmc +1 more source
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu +7 more
wiley +1 more source
A qualitative study on the current status and needs of unintentional injury prevention and control interventions for children aged 3-12 in Guizhou Province, China. [PDF]
Li X +10 more
europepmc +1 more source

