Results 71 to 80 of about 17,183 (156)

Towards a digital cancer cell twin: External pharmacological validation of a mechanistic A549 electrophysiology model

open access: yesClinical and Translational Discovery, Volume 6, Issue 1, February 2026.
A mechanistic in‐silico model of A549 lung adenocarcinoma electrophysiology reproduces drug‐modulated ion‐channel responses across wild‐type and erlotinib‐resistant phenotypes. By accurately capturing KCa1.1 and KCa3.1 inhibition and phenotype‐specific KCa remodelling within biologically plausible bounds, the model provides a validated foundation for ...
Celine Desoyer   +2 more
wiley   +1 more source

Forensic science: A judicial perspective. [PDF]

open access: yesProc Natl Acad Sci U S A, 2023
Rakoff JS, Liu G.
europepmc   +1 more source

A Tutorial on Optimal Dynamic Treatment Regimes

open access: yesStatistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT A dynamic treatment regime (DTR) is a sequence of treatment decision rules tailored to an individual's evolving status over time. In precision medicine, much focus has been placed on finding an optimal DTR which, if followed by everyone in the population, would yield the best outcome on average; and extensive investigations have been conducted
Chunyu Wang, Brian D. M. Tom
wiley   +1 more source

Reconciling Binary Replicates: Beyond the Average

open access: yesStatistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT Binary observations are often repeated to improve data quality, creating technical replicates. Several scoring methods are commonly used to infer the actual individual state and obtain a probability for each state. The common practice of averaging replicates has limitations, and alternative methods for scoring and classifying individuals are ...
H. Lorenzo, P. Pudlo, M. Royer‐Carenzi
wiley   +1 more source

A general approach to the linear stability of viscoelastic shear‐flows

open access: yesZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik, Volume 106, Issue 2, February 2026.
Abstract The present work provides an in‐depth analysis of the linear stability theory of viscoelastic shear‐flows, based upon a constitutive equation of the fading memory type. The particular model considered herein was introduced by Kenneth Walters through the integration of classical rate‐type fluids in a convected frame (Walters 1962).
Johannes Conrad, Martin Oberlack
wiley   +1 more source

Eyewitness testimony by individuals who stammer: Evidence, experience and perceived credibility

open access: yesBritish Journal of Psychology, Volume 117, Issue 1, Page 76-103, February 2026.
Abstract Stammering may impede an individual's eyewitness testimony and reduce jurors' perceptions of their credibility through a complex interplay of bio‐psycho‐social factors. However, no research to date has explored this. Three co‐produced, mixed‐methods studies are reported, investigating the evidential quality, lived experiences and perceived ...
Katie Maras   +13 more
wiley   +1 more source

Argumentation and explanation in the law. [PDF]

open access: yesFront Artif Intell, 2023
Rotolo A, Sartor G.
europepmc   +1 more source

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