Results 111 to 120 of about 7,735,964 (295)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform Toward Non‐Invasive Diagnostics

Advanced Science, EarlyView.
Maximizing Nanoscale Disorder in Block Copolymers for Orientation‐Independent SERS Platform toward Non‐Invasive Diagnostics is a nature‐inspired strategy that engineers controlled randomness within block copolymer lamellae to achieve optical isotropy without compromising nanoscale periodicity.
Jin Man Kim, Wonsik Kim, Wansun Kim, Yeon‐Hee Kim, Samjin Choi, Jang Hwan Kim, Hyeong Min Jin   +6 more
wiley   +1 more source

The epidemiological profile of pediatric patients admitted to the general intensive care unit in an Ethiopian university hospital

, 2015
Teshome Abebe, Mullu Girmay, Girma G/Michael, Million Tesfaye Department of Anesthesia, Jimma University, Jimma, Ethiopia Background: In least developing countries, there are few data on children's critical care.
Tesfaye M, Abebe T, G/Michael G, Girmay M   +3 more
core  

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

The effect of smoking on the severity, and mechanisms of acute exacerbations of chronic obstructive pulmonary disease (COPD)

, 2008
COPD (Chronic Obstructive Pulmonary Disease) worldwide has a prevalence of10% in men and 8.5% in women. Exacerbations of COPD account forapproximately 10% of all acute medical admissions.
Bourne, Simon Charles
core   +1 more source

Smartphone-assisted retinal evaluation in COVID-19 admitted patients

Indian Journal of Ophthalmology, 2021
Sandip Sarkar, Tanmay Gokhale, Y Farnaz, Amit Kumar Deb   +3 more
doaj   +1 more source

Deterioration Patterns in Patients Admitted for Severe COPD Exacerbation

Diseases
Background: Chronic obstructive pulmonary disease (COPD) exacerbations represent significant clinical events marked by worsening respiratory symptoms, often necessitating changes in medication or hospitalization.
Cristhian Alonso Correa-Gutiérrez, Zichen Ji, Irene Milagros Domínguez-Zabaleta, Javier Plaza-Hoz, Ion Gorrochategui-Mendigain, Ana López-de-Andrés, Rodrigo Jiménez-García, José Javier Zamorano-León, Luis Puente-Maestu, Javier de Miguel-Díez   +9 more
doaj   +1 more source

The prevalence and treatment outcomes of antineuronal antibody-positive patients admitted with first episode of psychosis

, 2018
BackgroundAntineuronal antibodies are associated with psychosis, although their clinical significance in first episode of psychosis (FEP) is undetermined.AimsTo examine all patients admitted for treatment of FEP for antineuronal antibodies and describe ...
Nagaraj Gundarpi, Robert J. Wilson, Sue Patterson, Wong, Richard CW, Gillis, David, Stefan Blum, Sean Hatherill, Peter Parry, Scott, James G, David Gillis, Martin P. Newman, Gundarpi, Nagaraj, Newman, Martin P, McKeon, Gemma, Prain, Kerri, Patterson, Sue, Alex E. Ryan, Ryan, Alex E, Hatherill, Sean, Kerri Prain, Hethal Hargovan, Richard C. W. Wong, Blum, Stefan, Gemma McKeon, Wilson, Robert J, James G. Scott, Parry, Peter, Hargovan, Hethal   +27 more
core   +1 more source

Soft, Multi‐Wavelength Photoplethysmography Enables Reliable Neonatal Blood Pressure Monitoring Via Error Stratification

Advanced Science, EarlyView.
A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi, Lanlan Mi, Jiarong Chen, Biao Liu, Min Wang, Zisheng Dai, Bin Liu, Ruize Gao, Yunfeng Lin, Weiwei Guo, Guoxing Wang, Wenyi Luo, Cheng Chen   +12 more
wiley   +1 more source