Results 111 to 120 of about 24,227 (189)

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Comparative Evaluation of Visual Observation, Digital Camera, and Smartphone Photography for Tooth Shade Selection: An In Vitro Study. [PDF]

Cureus
Jothisankar K, Mittal R, Madan R, Sardar M, Sinha N, Iman S, Rahman M, H NK, Gupta S.   +8 more
europepmc   +1 more source

Computing Skinning Weights via Convex Duality

Computer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

Counterillumination in a large demersal bioluminescent shark. [PDF]

iScience
Claes JM, Stevens DW, Mallefet J.
europepmc   +1 more source

Splatshop: Efficiently Editing Large Gaussian Splat Models

Computer Graphics Forum, EarlyView.
Abstract We present Splatshop, a highly optimized toolbox for interactive editing (selection, deletion, painting, transformation, …) of 3D Gaussian Splatting models. Utilizing a comprehensive collection of heuristic approaches, we carefully balance between exact and fast rendering to enable precise editing without sacrificing real‐time performance. Our
Markus Schütz, Christoph Peters, Florian Hahlbohm, Elmar Eisemann, Marcus Magnor, Michael Wimmer   +5 more
wiley   +1 more source

Chiral Coumarin Enantiomers From Prangos pabularia Roots: Absolute Configuration, Tyrosinase Activation, and Anti-Vitiligo Potential in B16F10 Cells. [PDF]

Chem Biodivers
Atolikshoeva S, Numonov S, Li J, Zhao J, Nueraihemaiti M, Gulmurodov I, Xuelei X, Maiwulanjiang M, Bozorov K, Askarov I, Yao G, Aisa HA.   +11 more
europepmc   +1 more source

Three‐Year Follow‐Up of Clinical, Radiographic, and Patient‐Reported Outcomes for Zirconia and Titanium Implants in the Posterior Region: A Randomized Controlled Trial

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objective To compare the 3‐year clinical, radiographic, esthetic, and patient‐reported outcomes of zirconia (Zr) and titanium (Ti) implants placed in posterior sites in a randomized, controlled within‐subject design. Materials and Methods Forty‐two patients each received one Zr and one Ti implant.
Anina N. Zuercher, Ronald E. Jung, Stefan P. Bienz, Stephanie A. Wenk, Daniel S. Thoma, Marc Balmer   +5 more
wiley   +1 more source

The SQSTM1 L341V Variant Associated With Sporadic ALS Promotes the Accumulation of Enlarged Ubiquitin-Positive SQSTM1 Bodies. [PDF]

Genes Cells
Shimakura K, Oka A, Yudahira H, Hama Y, Otomo A, Hadano S.   +5 more
europepmc   +1 more source

Crystal structure of human NIF3‐like protein reveals dynamic hexameric assembly with a single divalent metal binding site

The FEBS Journal, EarlyView.
We present the first crystal structures of human NIF3, revealing a dynamic, hexameric ring with a central cavity regulated by flexible insertion domains. Crucially, human NIF3 features a mononuclear zinc‐binding site, marking a distinct evolutionary departure from the dinuclear centers of bacterial homologs.
Elżbieta Wątor‐Wilk, Krzysztof Żak, Piotr Wilk, Paweł Kochanowski, Agnieszka Maślanka, Łukasz Skalniak, Przemysław Grudnik   +6 more
wiley   +1 more source

Study on stress response and collapse mechanism induced by shallow-buried defective pipelines in river alluvial plains. [PDF]

Sci Rep
Zhu Q, Shen Y, Han C, Wu G, Li Y.
europepmc   +1 more source