Results 11 to 20 of about 23,906 (189)

TRPC3-Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons. [PDF]

Adv Sci (Weinh)
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Lu Y, Zhao J, Xie Z, Wang Y, Wang R, Wang B, Shen C, Chen Y, Yao J, Li Z, Xu H, Chai Z, Zhang Z, Wang C, Huang R.   +14 more
europepmc   +2 more sources

Experimental Study of Mechanical Stabilization impact on Improving Compressive, Tensile and Flexural Strength of Adobe [PDF]

مسکن و محیط روستا, 2019
Iran is one of the oldest countries in the world benefiting from adobe-based architecture; a method which has long been forgotten in the contemporary architecture of country.
Mansoure Dormohamadi, Reza Rahimnia, Mohsen Fotuhi Ardakani   +2 more
doaj  

Assessing dehydration status in dengue patients using urine colourimetry and mobile phone technology.

PLoS Neglected Tropical Diseases, 2020
BackgroundDengue is a systemic and dynamic disease with symptoms ranging from undifferentiated fever to dengue shock syndrome. Assessment of patients' severity of dehydration is integral to appropriate care and management.
Natalie Chew, Abdul Muhaimin Noor Azhar, Aida Bustam, Mohamad Shafiq Azanan, Crystal Wang, Lucy C S Lum   +5 more
doaj   +1 more source

The Dynamic Properties of Historic Timber-Framed Masonry Structures in Bursa, Turkey

Shock and Vibration, 2018
Timber-framed masonry structures are known as an effective earthquake load resisting system in high seismicity regions such as Bursa, Turkey. Intense earthquakes have occurred throughout history; however, many of the traditional timber structures have ...
M. Bilal Bağbancı, Özlem Köprülü Bağbancı   +1 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Integrating technological solutions to identify the potential locations for rainwater harvesting interventions in ICAR-IIHR farm at Hesaraghatta, Bengaluru

Journal of Horticultural Sciences, 2017
Water constitutes the prime requirement for existence and sustenance of all life forms. It is also the most vital component for enabling economic and social development.
Bhanu A, Suresh Ramaswwamyreddy
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Teaching support material on reference values of clinical laboratory tests

Universidad Médica Pinareña, 2020
Introduction: due to the diagnostic utility of complementary clinical laboratory tests, it is necessary to learn from undergraduate to achieve better medical care.
Carlos Alfredo Miló-Valdés, Emilio Yaser Pando-Hernández, Humbelina Díaz-Alfonzo, Yanisleidi Bravo-Malagón   +3 more
doaj   +2 more sources