Results 231 to 240 of about 308,808 (316)

External validation of a therapeutic window for risperidone in children with autism spectrum disorder

British Journal of Clinical Pharmacology, EarlyView.
Abstract Although risperidone is an effective pharmacological intervention for managing disruptive behaviour in children with autism spectrum disorder, it may induce metabolic side effects. This study aimed to externally validate the population pharmacokinetic (popPK) model and the therapeutic window of 3.5–7 ng/mL of risperidone and 9‐OH‐risperidone ...
Rebecca A. Hermans, Kathalijne Bruens, Karin M. Egberts, Birgit C. P. Koch, Bram Dierckx, Manon H. J. Hillegers, Marcel Romanos, Regina Taurines, Stefanie Fekete, Khatia Eisenecker, Hans‐Willi Clement, Christian Fleischhaker, Brenda C. M. de Winter   +12 more
wiley   +1 more source

Remember Me? Adolescent Thalamic Inhibition Leads to Deficits in Cortical Maturation and Social Memory. [PDF]

Biol Psychiatry Glob Open Sci
Bravo I, Kellendonk C.
europepmc   +1 more source

Real‐world population pharmacokinetics of tezacaftor‐ivacaftor in children with cystic fibrosis: The SYM‐CF study

British Journal of Clinical Pharmacology, EarlyView.
Aims The clinical effectiveness of tezacaftor‐ivacaftor in children with cystic fibrosis (cwCF) varies; some patients respond while others do not or have adverse effects. The pharmacokinetics (PK) of tezacaftor‐ivacaftor are inadequately published, especially in children.
Steffie E. M. Vonk, Suzanne W. J. Terheggen‐Lagro, Eric G. Haarman, Hettie M. Janssens, Anke‐Hilse Maitland–van der Zee, E. Marleen Kemper, Ron A. A. Mathôt, on behalf of the Amsterdam Mucociliary Clearance Disease (AMCD) research group   +7 more
wiley   +1 more source

Contribution of Addictovigilance data to assess adverse‐events linked to psychoactive substances in children and adolescents

British Journal of Clinical Pharmacology, EarlyView.
Aims We sought to characterize adverse events and deaths associated with the use of psychoactive substances in children and adolescents. Methods Two French Addictovigilance databases were analysed: spontaneous reports and deaths over the period 2016–2021, in subjects aged 10–<18 years. An unsupervised classification was implemented on consumption data (
Hélène Peyrière, Anne Batisse, Nathalie Fouilhé Sam‐Laï, Amélie Daveluy, Christine Fournier‐Choma, Sylvie Deheul, Cécile Chevalier, Clémence Lacroix, Valérie Gibaja, Aurélie Aquizerate, Stéphanie Pain, Emilie Jouanjus, Marie‐Christine Picot, Erika Nogue   +13 more
wiley   +1 more source

Predictive ability of plasma concentration of triglyceride/high density lipoprotein-cholesterol ratio for cardiometabolic variables in a sub-Sahara black African adolescent population-Nigerians. [PDF]

PLoS One
Holdbrooke SJ, Afolabi BM.
europepmc   +1 more source

Cefuroxime axetil dosing regimens and probability of target attainment in adults and children

British Journal of Clinical Pharmacology, EarlyView.
Aims Cefuroxime axetil exists in several dosage forms for oral administration, and is indicated for treatment of respiratory, genitourinary, skin and soft tissue infections. Evolving patterns of bacterial susceptibility, expressed as increasing minimum inhibitory concentrations (MICs), warrant monitoring of antibiotic efficacy.
Sven C. van Dijkman, Praveen Kamble, Jerzy A. Kowalski, Oscar Della Pasqua   +3 more
wiley   +1 more source

The interaction among household chaos, parental rejection, and parental control in predicting adolescent executive function. [PDF]

Dev Psychol
Hong Y, Folker AE, Deater-Deckard K, Skinner AT, Steinberg L, Bornstein MH, Dodge KA, Lansford JE.   +7 more
europepmc   +1 more source

Trends in opioid prescribing in Scandinavian countries from 2010 to 2023: Insights from multi‐metric evaluation

British Journal of Clinical Pharmacology, EarlyView.
Aims Monitoring opioid prescribing across different healthcare systems is essential to understanding population‐level exposure and informing global health policies. This study examined opioid utilization in Scandinavian countries between 2010 and 2023 using multiple complementary metrics, addressing the limitations of single‐metric comparisons ...
Gabriela Rolová, Svetlana Skurtveit, Marte Handal, Geana Paula Kurita, Torgeir Gilje Lid, Ingvild Odsbu, Mikael Hoffmann   +6 more
wiley   +1 more source

Sex differences in visually guided orienting behavior emerges during adolescence in mice. [PDF]

iScience
Gonzalez-Olvera R, Allen K, Feng T, Hoy JL.   +3 more
europepmc   +1 more source

Effectiveness and safety of interventions for fever‐associated discomfort in children: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Aims Fever is one of the most frequent reasons for paediatric consultations. While traditionally managed by reducing body temperature, recent guidelines emphasize alleviating discomfort as the primary therapeutic goal. Although different interventions have been described to manage fever‐associated discomfort in children, their effectiveness and safety ...
Antonio Corsello, Ilaria Alberti, Sara Farhanghi, Alessia Bonetti, Silvia Garattini, Anna Comotti, Paola Marchisio, Elena Chiappini, Gregorio Paolo Milani   +8 more
wiley   +1 more source