Results 81 to 90 of about 1,265,640 (297)

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source

Treating Taylor: Multidisciplinary Management of Eating Disorders

MedEdPORTAL, 2014
Introduction Eating disorders (EDs) are a source of significant morbidity and mortality among youth in the United States. The lifetime prevalence rates of anorexia nervosa, bulimia nervosa, and binge eating disorder during adolescents are 0.3%, 0.9%, and
Kendrin Sonneville, Melissa Freizinger, Sara Forman, Pamela Burke, Adrianne Goncalves, Sarah Pitts, Holly Gooding   +6 more
doaj   +1 more source

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

Advanced Science, EarlyView.
This study identifies that REGγ is elevated in obese adipose tissue. REGγ modulates WAT browning via ubiquitin‐independent ACADM/KLF15–UCP1 degradation. Overactivation of the NRF2–REGγ axis facilitates adipose tissue function to cause obesity. Inhibition of REGγ in the iWAT alleviates HFD‐induced obesity.
Hui Chen, Qiujing Guan, Shuangming Gong, Yingying Du, Zhidan Zhang, Yan Liu, Lei Zhou, Lin Liu, Baoquan Xin, Yilan Guo, Hui Zhang, Ziyang Zhou, Tongchao Pei, Guohong Yu, Sokun Yin, Lei Li   +15 more
wiley   +1 more source

Family-based treatment at home in adolescents with eating disorders and co-occurring mental health conditions: rationale and study design of a mixed methods trial

BMC Psychiatry
Background The significant impact of eating disorders on adolescents necessitates the evaluation of current treatments. Family-based Treatment (FBT) is the standard treatment but has modest remission rates, highlighting the need for improvements ...
Andrea A. H. Schapink, Jildou van der Velde, Katie Winkelhorst, Shireen Kaijadoe, Hermien H. J. Elgersma, Daniel Le Grange, Rik Knipschild, Helen Klip   +7 more
doaj   +1 more source

Gee-Thaysen Disease: Idiopathic Steatorrhoea of Adults and Adolescents in Non-tropical Countries [PDF]

, 1941
John O’Sullivan, Henry Moore
openalex   +1 more source

A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM)

Advanced Science, EarlyView.
A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri, Adam Nyul‐Toth, Madison Milan, Eva Troyano‐Rodriguez, Sherwin Tavakol, Jennifer Ihuoma, Zeke Reyff, Rakesh Rudraboina, Rafal Gulej, Raymond Jang, Anna Csiszar, Zoltan Ungvari, Audrey Cleuren, David R Miller, Andriy Yabluchanskiy, Mickael Tanter, Stefano Tarantini   +16 more
wiley   +1 more source

Child and Adolescent Life in Health and Disease [PDF]

, 1946
George The, Terry Lectures
openalex   +1 more source

Millikelvin Intracellular Nanothermometry with Nanodiamonds

Advanced Science, EarlyView.
Nanothermometry in living cells is crucial for understanding heat diffusion and advancing cellular biology and drug discovery. Previous studies have reported controversial intracellular temperature variations. Using nanodiamond nanothermometry in macrophages, it is found that, in such experimental setting, apparent temperature changes are actually due ...
Maabur Sow, Jacky Mohnani, Genko Genov, Raphael Klevesath, Elisabeth Mayerhoefer, Yuliya Mindarava, Rémi Blinder, Soumen Mandal, Fabien Clivaz, Raúl B. Gonzalez, Daniel Tews, Christian Laube, Wolfgang Knolle, Amelie Jerlitschka, Farid Mahfoud, Oleg Rezinkin, Mateja Prslja, Yingke Wu, Pamela Fischer‐Posovszky, Martin B. Plenio, Susana F. Huelga, Tanja Weil, Anke Krueger, Gavin W. Morley, Oliver A. Williams, Steffen Stenger, Fedor Jelezko   +26 more
wiley   +1 more source

Long-Term Consequences of Misdiagnosis of Parathyroid Adenomas in Pediatric Patients

Case Reports in Pediatrics
Primary hyperparathyroidism (PHPT) is rare in children but exhibits a more dynamic course than in adults, often leading to multiorgan complications if diagnosis is delayed.
Dorota Roztoczyńska, Aleksander Konturek, Anna Wędrychowicz, Magdalena Ossowska, Alicja Kapusta, Anna Taczanowska-Niemczuk, Jerzy B. Starzyk   +6 more
doaj   +1 more source

Stiffness of the Great Toe Joint in Male Adolescents [PDF]

, 1887
Howard Marsh
openalex   +1 more source