Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang +5 more
wiley +1 more source
Visible Pregnancy, Invisible HIV: How Social Norms Shape Adolescents Protection Choice in Kenya and Nigeria. [PDF]
Bitère C +3 more
europepmc +1 more source
Aims Tranexamic acid (TXA) stabilizes clot formation by inhibiting fibrin degradation and improves postoperative outcomes. However, rare adverse events (e.g., thrombosis, seizures) warrant dose–risk evaluation. This study examines how perioperative blood loss and transfusion practices affect TXA concentrations during paediatric scoliosis surgery ...
Paula Alexandra Sá +4 more
wiley +1 more source
The chain mediating role of consolidated helicopter parenting and impulsivity in the physical activity to adolescent aggressive behavior. [PDF]
Liu M +5 more
europepmc +1 more source
Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Abstract Aims Children with primary immunodeficiency (PID) and secondary antibody deficiency (SAD) often require immunoglobulin replacement therapy due to low plasma immunoglobulin G (IgG) levels and recurrent infections. Existing pharmacokinetic models for immunoglobulin in PID patients predominantly focus on adults, with limited attention to ...
Iek Leng Cheng +4 more
wiley +1 more source
The relationship between family physical activity environment and mental health in high school students: the chain mediating role of parent-child relationship and exercise behavior. [PDF]
Feng X, Xu E.
europepmc +1 more source
Understanding Adolescent Non-Suicidal Self-Injury: A Narrative Review of Theoretical Models and Evidence-Based Psychotherapies. [PDF]
Kweon K.
europepmc +1 more source

