Results 51 to 60 of about 471,882 (266)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Neurodevelopmental Disorders, Cognitive Function, and Quality of Life in Children with Congenital Hypothyroidism in a Portuguese Population

JCRPE
Objective: Although neonatal screening programs have reduced severe intellectual disability, children with congenital hypothyroidism (CH) are still at risk for neurodevelopmental deficits and a lower quality of life (QoL).
Laura Leite-Almeida, Rita Curval, Inês Pais-Cunha, Bárbara Pereira-Neto, Sofia Ferreira, Rita Santos Silva, Micaela Guardiano, Paulo Almeida, Cíntia Castro-Correia   +8 more
doaj   +1 more source

Mapping Occupational Therapy Practice with Postsecondary Students: A Scoping Review

Open Journal of Occupational Therapy, 2020
Background: Legislation supports a role for occupational therapy in postsecondary settings, but this area is not a common practice area and the practice area is not well understood.
Karen M. Keptner, Karen McCarthy
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The right age to fall in love

Journal of Family Medicine and Primary Care
Adolescents exploring sexual aspects and engaging in intimate acts with romantic partners is a normal part of development. However, in India, adolescent romantic relationships are influenced by complex sociocultural factors.
Pallavi Abhilasha, Nikhil Gautam, Hayash Teenoth, Shaveta Bhardwaj   +3 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Adolescent Profiles Amid Substantial Adverse Childhood Experiences: A Latent Profile Analysis on Personality, Cognitive, Behavioral, and Social Outcomes

Adolescents
Background: Adolescence is a critical period of rapid physical and psychological change, yet it is also when many health and well-being problems first emerge, often setting limits on lifelong opportunities and achievements as youth transition into ...
Xiafei Wang, Xiaoyan Zhang, Gabriel J. Merrin   +2 more
doaj   +1 more source

Avaliação das medidas do comprimento peniano de crianças e adolescentes Penile anthropometry in Brazilian child and adolescent

Jornal de Pediatria, 2007
OBJETIVO: Classicamente, o pênis tem duas funções: permitir a fertilização interna e direcionar o jato miccional. Entretanto, alterações objetivas do tamanho peniano podem levar ao diagnóstico de doenças.
Pedro N. Gabrich, Juliana S. P. Vasconcelos, Ronaldo Damião, Eloísio A. da Silva   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Comparative Effects of Repeated Linear Sprint and Change-of-Direction Speed Training on Performance, Perceived Exertion and Enjoyment in Youth Soccer Players

Sports
Youth soccer requires an integrated approach combining technical–tactical, physical, and psychological components to enhance performance and long-term engagement.
Okba Selmi, Mohamed Amine Rahmoune, Hamza Marzouki, Bilel Cherni, Anissa Bouassida, Antonella Muscella, Santo Marsigliante, Jolita Vveinhardt, Wafa Douzi   +8 more
doaj   +1 more source