Results 71 to 80 of about 12,660,385 (288)

Involvement of sphingosine-1-phosphate receptor 1 in pain insensitivity in a BTBR mouse model of autism spectrum disorder

BMC Medicine
Background Abnormal sensory perception, particularly pain insensitivity (PAI), is a typical symptom of autism spectrum disorder (ASD). Despite the role of myelin metabolism in the regulation of pain perception, the mechanisms underlying ASD-related PAI ...
Lili Fan, Qi Li, Yaxin Shi, Xiang Li, Yutong Liu, Jiaqi Chen, Yaqi Sun, Anjie Chen, Yuan Yang, Xirui Zhang, Jia Wang, Lijie Wu   +11 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The association between parental mental health and screen time among U.S. children aged 6–17

BMC Psychology
Objective To examine the association between parental psychological symptoms and children’s screen media behavior based on the data from a nationally representative sample. Methods This study included 3,974 children aged 6 to 17 years.
Shiqi Qiu, Yingmin Cao, Shan Chen, Genyuan Li, Yangsheng Liu, Yun Wang, Xia Zeng, Mingyang Yuan, Wenhan Yang   +8 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Bullying : health, well-being and risk behaviours [PDF]

, 2011
The HBSC Study in Scotland is funded by NHS Health ...
Alexander, L, Mellor, A, Currie, Candace
core   +2 more sources

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Adolescence and Public Health

American Journal of Public Health and the Nations Health, 1941
DEMOGRAPHIC AND MORTALITY DATA First, as to the demographic and mortality picture during the second decade. The continued decline in the birth rate, which was reflected in the 1940 census by a further reduction in the number of children under 5, has not yet influenced the number of adolescents, but it is clear that within the next decade there wir be a
openaire   +3 more sources

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Socioeconomic inequalities in adolescent health 2002-2010 : a time-series analysis of 34 countries participating in the Health Behaviour in School-aged Children study [PDF]

, 2015
The study was supported by research grants from the Canadian Institutes for Health Research, the Social Sciences and Humanities Research Council of Canada, and the Canada Research Chairs programme awarded to FJE.
Moor, Irene, Leerstoel Vollebergh, Stevens, Gonneke W.J.M., Pförtner, Timo Kolja, Elgar, Frank J, Stevens, Gonneke WJM, Pförtner, Timo-Kolja, Elgar, Frank J., De Clercq, Bart, Stevens, Gonneke W J M, Youth in Changing Cultural Contexts, Currie, Candace   +11 more
core   +2 more sources