Results 101 to 110 of about 1,301,608 (363)

Lactate Activates the HCAR1/β‐Arrestin2/PP2A Signaling Axis to Mediate STAT1/2 Dephosphorylation and Drive Osteosarcoma Progression

Advanced Science, EarlyView.
In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han, Qi Jia, Guangjian Bai, Zhao Li, Jin Zeng, Zhenhua Wang, Jing Zhang, Jiashi Cao, Baoquan Xin, Yonggang Liu, Jingyu Shen, Lining Wang, Xing Huang, Chunlei Zhang, Kai Tong, Fenglei Dai, Yajie Zhang, Weina Zhu, Songyi Cheng, Yuanming Chen, Xinghai Yang, Guanghui Chen, Zhenhua Zhou, Yong Ma, Weibo Liu, Ting Wang, Tielong Liu   +26 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Conocimientos y Prácticas sobre lactancia materna exclusiva en adolescentes embarazadas que asisten a atención prenatal al Hospital Amistad México-Nicaragua, Ticuantepe–Managua II semestre 2016 [PDF]

, 2016
En los últimos años se ha visto un aumento de embarazos en adolescentes entre 12 y 18 años, con ello una gran disminución en la práctica de la lactancia materna, ya que las madres no llegan ni a los 6 meses dando lactancia materna exclusiva. Este estudio
Blas Hernández, Zelmira Walkiria, Fernández Sánchez, Geysel María, Galán Mercado, Damaris   +2 more
core  

FGF9–FGFR2 Signaling via Osteocytes‐Preosteoblasts Crosstalks to Mediate Mechanotransduction‐Driven Intramembranous Osteogenesis in the Underdeveloped Maxilla

Advanced Science, EarlyView.
This study identifies osteocyte‐derived FGF9 as a mechanosensitive factor that impairs osteogenesis in the underdeveloped maxilla by inducing FGFR2 nuclear translocation in preosteoblasts. Mechanical stimulation reduces FGF9 secretion, relieving its inhibitory effect. These findings reveal a novel osteocyte–preosteoblast FGF9–FGFR2 axis in craniofacial
Yiwen Zhou, Lili Chen, Miaomiao Han, Peixiang Zhu, Yanyi Wang, Xuanxuan Yu, Tingyu Reng, Huijuan Wang, Baochao Li, Caixia Zhang, Ziwei Huang, Shuang Lin, Guoyun Wang, Jie Ge, Baosheng Guo, Huang Li   +15 more
wiley   +1 more source

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

Del fracaso en los sistemas escolares o la fábrica del alumno competente

Voces de la educación, 2016
Afirmar el fracaso de los sistemas escolares en su intento por lograr una verdadera democratización de la escuela no es una mera opinión. Bajo el pretexto de promover una mayor igualdad, las políticas neoliberales simplemente buscan el rendimiento ...
Angelique Del Rey
doaj  

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

Redox Biology, 2018
In the last few decades, many reports have suggested that mitochondrial function impairment is a hallmark of Alzheimer's disease (AD). Although AD is a neurodegenerative disorder, mitochondrial damage is also present in patients’ peripheral tissues ...
María José Pérez, Daniela P. Ponce, Alejandra Aranguiz, Maria I. Behrens, Rodrigo A. Quintanilla   +4 more
doaj   +1 more source

EMBARAZO EN ADOLESCENTES

Revista Peruana de Ginecología y Obstetricia, 2015
OBJETIVO: Analizar las características perinatales en mujeres gestantes adolescentes. DISEÑO: Estudio retrospectivo, descriptivo. LUGAR: Hospital Nacional Rebagliati Martins, EsSalud, hospital docente. MATERIALES Y MÉTODOS: Se analiza todos los partos en adolescentes atendidos durante el período enero 2000 a diciembre 2004. RESULTADOS: Hubo un total de
Claudia Urbina, José Pacheco
openaire   +2 more sources

Percepção e Satisfação Corporal em Adolescentes e a Relação com a sua Saúde Oral [PDF]

, 2011
Introdução: A autopercepção e satisfação com a imagem corporal são factores preponderantes na autoaceitação dos adolescentes e entre os seus pares.
Agostinho, Joana, Albuquerque, Inês, Bica, Isabel, Costa, José dos Santos, Cunha, Madalena, Lima, Teresa, Neves, Daniela, Pereira, Sandra, Rodrigues, Vítor   +8 more
core  

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source