Results 101 to 110 of about 1,557,731 (346)

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Pai adolescente

Revista Brasileira de Sexualidade Humana, 1998
.
Ellika Trindade, Maria Alves de Toledo Bruns   +1 more
openaire   +2 more sources

Motivos e prevalência de insatisfação com a imagem corporal em adolescentes

, 2012
OBJETIVO: Verificar os motivos e a prevalencia de insatisfacao com a imagem corporal (IC) em adolescentes. Metodos: Participaram do estudo 641 adolescentes de 11 a 17 anos. A imagem corporal foi autoavaliada atraves da escala de nove silhuetas corporais.
E. L. Petróski, Andreia Pelegrini, M. F. Glaner   +2 more
semanticscholar   +1 more source

Cognitive Behavioral Therapy for Youth with Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, Accepted Article.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source

Adolescências... Adolescentes...

Millenium, 2006
A adolescência é hoje conceptualizada como o período situado entre a infância e a vida adulta. Inicia-se com os primeiros indícios físicos da maturidade sexual e termina com a realização social da situação de adulto independente. No mundo ocidental, corresponde mais ou menos à época entre os 12 e os 20 anos, contudo existem oscilações deste período ...
Ferreira, Manuela, Nelas, Paula Batista
openaire   +3 more sources

Onset of adolescent eating disorders: population based cohort study over 3 years [PDF]

, 1999
George Patton, R Selzer, Carolyn Coffey, John B. Carlin, Rory Wolfe   +4 more
openalex   +1 more source

Ideações e tentativas de suicídio em adolescentes com práticas sexuais hetero e homoeróticas

, 2012
Esta pesquisa, que teve como populacao-alvo adolescentes com idade entre 12 e 20 anos, residentes em tres municipios do interior Paulista, buscou conhecer as associacoes entre orientacao sexual e ideacoes e tentativas de suicidio.
Fernando Teixeira-Filho, C. Rondini
semanticscholar   +1 more source

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

Early manifestations of autism spectrum disorders. Experience of 393 cases in a child neurological centre

Neurología (English Edition), 2012
Introduction: The autism spectrum disorders are group of conditions characterised by qualitative impairments in social communication; in the interaction and imagination; with a restricted range of interests and stereotyped repetitive behaviours ...
A. Bravo Oro, J. Vázquez Briseño, C.A. Cuello García, R.F. Calderón Sepúlveda, A.M. Hernández Villalobos, C. Esmer Sánchez   +5 more
doaj   +1 more source