Results 101 to 110 of about 1,340,927 (354)

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

open access: yesAdvanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu   +20 more
wiley   +1 more source

Factores y Consecuencias del Inicio de Vida Sexual Activa en las y los Adolescentes que asisten al puesto de salud las palomas del municipio de Sébaco, departamento de Matagalpa, II semestre 2015 [PDF]

open access: yes, 2016
El inicio de la vida sexual activa no solo se refiere al coito, sino a distintas prácticas sexuales como besos, caricias, roces que deben ser experimentadas con responsabilidad para tener una salud sexual sana y placentera, este estudio se aborda con el ...
Ruíz Dávila, Mirna del Socorro   +1 more
core  

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

open access: yesAdvanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang   +6 more
wiley   +1 more source

A Placebo Controlled Crossover Trial of Liquid Fluoxetine on Repetitive Behaviors in Childhood and Adolescent Autism [PDF]

open access: bronze, 2004
Eric Hollander   +6 more
openalex   +1 more source

Conocimientos actitudes y prácticas sobre Métodos anticonceptivos en los adolescentes que asisten a la Clínica de Planificación Familiar del Centro de Salud “Villa Libertad”, del Municipio de Managua, Departamento de Managua, en el periodo del 1° de Febrero al 31 de Mayo del 2013 [PDF]

open access: yes, 2015
Hasta hace pocos años la Salud Sexual y Reproductiva fue reconocida como parte integral del proceso de equilibrio de salud en el hombre, además la mayoría de los países en vía de desarrollo no contaban con verdaderos programas dirigidos de forma directa ...
Bustamante Escobar, Karina Iveth   +1 more
core  

Early manifestations of autism spectrum disorders. Experience of 393 cases in a child neurological centre

open access: yesNeurología (English Edition), 2012
Introduction: The autism spectrum disorders are group of conditions characterised by qualitative impairments in social communication; in the interaction and imagination; with a restricted range of interests and stereotyped repetitive behaviours ...
A. Bravo Oro   +5 more
doaj   +1 more source

A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM)

open access: yesAdvanced Science, EarlyView.
A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri   +16 more
wiley   +1 more source

Conducta suicida en adolescente con trastorno del neurodesarrollo: ¿Autismo o Psicosis emergente?

open access: yesPsicosomática y Psiquiatría, 2021
María Rosario Pérez Moreno   +1 more
doaj   +1 more source

Hot‐Pressing Annealing‐Induced Light Utilization Enhancement and Crystallinity Optimization Enable High‐Performance Narrowband Ultraviolet Photodetectors for Real‐Time Ultraviolet Radiation Monitors

open access: yesAdvanced Science, EarlyView.
By utilizing a hot‐pressing (HP) annealing strategy, Cs3Cu2I5 films with larger grains vertically spanning the entire thickness are fabricated. Because HP annealing enhances light utilization and charge transport in Cs3Cu2I5/GaN heterojunction, the HP device achieves superior detection performance while maintaining narrowband photoresponse to UVA/UVB ...
Jingli Ma   +13 more
wiley   +1 more source

Conductas de riesgo en una muestra de adolescentes chilenos y mexicanos: un estudio comparativo [PDF]

open access: yes, 2011
Los adolescentes son una población cuya morbilidad y mortalidad se relacionan estrechamente con determinados factores y conductas de riesgo. Por otro lado, la familia y los estilos de vida saludables son factores que se relacionan con una disminución de ...
BORQUEZ PUGA, MARIANA   +15 more
core  

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