Results 261 to 270 of about 1,301,608 (363)

Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas

open access: yesAnnals of Neurology, EarlyView.
Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek   +7 more
wiley   +1 more source

Experience of adolescents/young adults with chronic kidney disease and of their families during transition of care. [PDF]

open access: yesRev Esc Enferm USP
Roveri JR   +5 more
europepmc   +1 more source

Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early‐Onset Parkinsonism

open access: yesAnnals of Neurology, EarlyView.
Objective Autophagy is a fundamental biological pathway with vital roles in intracellular homeostasis. During autophagy, defective cargoes including mitochondria are targeted to lysosomes for clearance and recycling. Recessive truncating variants in the autophagy gene EPG5 have been associated with Vici syndrome, a severe early‐onset neurodevelopmental
Hormos Salimi Dafsari   +140 more
wiley   +1 more source

The impact of the COVID-19 pandemic on the lives of the 2004 Pelotas (Brazil) birth cohort adolescents. [PDF]

open access: yesCad Saude Publica
Matijasevich A   +5 more
europepmc   +1 more source

La problématique adolescente

open access: yes, 2016
Si l'on veut tenter de comprendre les enjeux de l'adolescence, il faut avant tout la distinguer de la puberté. Elle relève de processus spécifiquement humains, alors que la puberté participe, quant à elle, du registre physiologique et des lois qui en rendent compte.
openaire   +1 more source

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

open access: yesAnnals of Neurology, EarlyView.
Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and disease.
Nico J. Diederich   +20 more
wiley   +1 more source

Observatório AlenRiscos - Prevention of the consumption of psychoactive substances among adolescents 3rd cycle. [PDF]

open access: yesRev Bras Enferm
Dias AMGDS   +7 more
europepmc   +1 more source

Early life functional transitions impact craniofacial morphology in osteogenesis imperfecta

open access: yesThe Anatomical Record, EarlyView.
Abstract Early life behaviors have a profound role in shaping adult craniofacial morphology. During early life, all mammals undergo the dynamic transition from suckling to mastication, a period coinciding with rapid cranial biomineralization. Osteogenesis imperfecta (OI), a genetic disorder that impacts the production of type I collagen, disrupts ...
Courtney A. Miller   +2 more
wiley   +1 more source

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