Results 71 to 80 of about 1,301,608 (363)

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease

Frontiers in Neuroscience, 2017
The identification of an early biomarker to diagnose Alzheimer's disease (AD) remains a challenge. Neuropathological studies in animal and AD patients have shown that mitochondrial dysfunction is a hallmark of the development of the disease.
María J. Pérez, María J. Pérez, Daniela P. Ponce, Cesar Osorio-Fuentealba, Cesar Osorio-Fuentealba, Maria I. Behrens, Rodrigo A. Quintanilla, Rodrigo A. Quintanilla   +7 more
doaj   +1 more source

Propiedades psicométricas del Cuestionario de Adicción a Internet y a los Videojuegos para Adolescentes [PDF]

, 2018
El propósito del presente estudio fue desarrollar un instrumento que evalúe en adolescentes la adicción a internet y a los videojuegos. La muestra estuvo compuesta por 354 adolescentes (M = 13.75, DE = 1.89).
Chahín-Pinzón, Muñoz-Rivas, Navas, Psychiatric Association, Rueda-Jaimes   +4 more
core   +3 more sources

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Enhancing the Effectiveness of Chemotherapy in Osteosarcoma by Targeting Tumour‐Associated Macrophages (TAMs) through STING Activation

Advanced Therapeutics, EarlyView.
Osteosarcoma isa highly aggressive bone cancer with an immunosuppressive tumor microenvironment that limits immunotherapy. This study explores STING pathway activation to reprogram tumor‐associated macrophages into a tumoricidal M1‐like phenotype and enhance doxorubicin efficacy. Results show that doxorubicin alone failed to activate the STING pathway,
Jordan C. O'Donoghue, Amanda Guitián‐Caamaño, Maeve Boyce, Fiona E. Freeman   +3 more
wiley   +1 more source

Tipologías y razones de aparición de la política pública de la infancia en Colombia 1930-2012

Sociedad y Economía, 2014
El presente artículo describe y analiza la política pública de los niños, niñas y adolescentesen Colombia a partir del surgimiento del Estado proteccionista (1930) hasta la llegada delEstado neoliberal (1984-presente). Por medio de una revisión histórica,
Camilo Bácares Jara
doaj   +1 more source

Rastreio de escoliose no adolescente [PDF]

Revista Portuguesa de Clínica Geral, 2011
No artigo «Boletim de Saúde Infantil e Juvenil - o exame global de saúde dos 11 aos 13 anos (parte II)»,1 é referida a importância da realização do rastreio de escoliose no exame global de saúde dos 11 aos 13 anos, através da realização, entre outros, da manobra de Adams.
openaire   +4 more sources

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

“I want but I can´t”. A description about the resistances and limits in a groupwork of Art-therapy concerning domestic violence, through the evolution of a concrete case

Arteterapia, 2013
We will enter the process of a participant following her journey through an experience in an arttherapy groupwork concerning domestic violence. Her attitude of "I want but I can't" will help us to reflect about the unconscious resistances that arise ...
Pilar Ascaso Palacín
doaj   +1 more source

Adolescentes y embarazo

Revista Colombiana de Obstetricia y Ginecología, 1989
Se revisaron las historias clínicas de 596 pacientes adolescentes embarazadas que fueron atendidas en el Hospital General de Neiva y que constituyeron el 24.5% de la población de maternas, en el período de un año, comprendido entre el lo. de junio de 1987 y el 31 de mayo de 1988.Encontramos que los factores sicológicos y sociales son los más ...
openaire   +4 more sources