Results 111 to 120 of about 1,160,289 (319)

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

2013 APA Bronze Award: Family-Based, Integrated Care for Children and Adolescents With Complex Pediatric Illness [PDF]

, 2013

openalex   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Adolescent Development in Unprecedented Times: A Comparative Study of Theory of Mind Before and After COVID-19

Adolescents
The coronavirus disease of 2019 (COVID-19) pandemic represented a significant global event that disrupted the typical social lives of adolescents. Studies show that the pandemic negatively impacted adolescent well-being.
Meghan L. Maynard, Huma Khalid, Zahra Karimi Valoojerdy, Victoria Talwar, Sandra L. Bosacki   +4 more
doaj   +1 more source

Clinical and Laboratory Characteristics of Periodontal Disease in Adolescents with Type 1 Diabetes [PDF]

Georgiy Khetagovich Kibizov, Yana Makharbekovna Bedoeva, Angelina Zoltanovna Kazieva, Lana Rafikovna Makieva, Irina Aleksandrovna Tokaeva, Diana Olegovna Gudieva, Iman Alamovna Muzaeva, Alexandr Elkanovich Kharebov, Anastasia Igorevna Shmailova, Maryam Muradovna Alangerieva   +9 more
openalex   +1 more source

Decision letter for "<scp>Self‐Management</scp> Among Pre‐teen and Adolescent Diabetes Device Users"

, 2020

openalex   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Predictive Markers and Self-Perceived Health in Adolescents: An Exploration Through a School-Based Public Health Survey

Adolescents
Adolescence is a critical developmental stage marked by significant physical, emotional, and social changes that profoundly influence health behaviors.
José Antonio Zafra-Agea, Mireia Vilafranca-Cartagena, Daniel García-Gutiérrez, Estel·la Ramírez-Baraldes, Anna Portabella-Serra, Cristina García-Salido   +5 more
doaj   +1 more source

Consumo de alcohol en ratas adolescentes tratadas con reserpina y fluoxetina

, 2017
Paúl Ruiz, Aldo Calliari, Ricardo Marcos Pautassi   +2 more
openalex   +1 more source

Data set for manuscript "Optimal utilization of PMTCT of HIV services among adolescents under group versus focused antenatal care"

, 2022
AKUNZIRWE REBECCA
openalex   +1 more source