Results 51 to 60 of about 592,910 (266)

The Ambivalence of Adoption: Adoptive Families’ Stories [PDF]

Sociology, 2019
The making of family through adoption is an emotionally and politically charged legal and social process. Both its historical and contemporary manifestations are characterised by ambivalence. Contemporary domestic adoption in the UK is at a point of profound reflection, as many of its ambivalent features are articulated at the levels of national policy
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Exploring the Benefits of Mass Timber Construction in the Workplace: A Novel Primer for Research

Buildings
Mass timber construction has recently gained popularity due to its outstanding environmental benefits and building performance, which hold revolutionary potential for the construction industry.
Stephen Whyte, Ryotaro Kaburagi, Victor Gan, Christhina Candido, Behnaz Avazpour, Dorsa Fatourehchi, Ho Fai Chan, Yue Dong, Uwe Dulleck, Sabine Finlay, Jin Zhou, Nick Hewson, Tong Li, Duncan Maxwell, Craig McNulty, Zoltan Sarnyai   +15 more
doaj   +1 more source

The NHS Care Record Service (NHS CRS): recommendations from the literature on successful implementation and adoption

Journal of Innovation in Health Informatics, 2009
The implementation of the National Health Service's Care Record Service (NHS CRS) is the most ambitious information technology innovation ever undertaken in healthcare.
Kathrin Cresswell, Aziz Sheikh
doaj   +1 more source

Implications for Adoption [PDF]

Proceedings of the 2017 CHI Conference on Human Factors in Computing Systems, 2017
In this paper we explore the motivations for, and practicalities of, incorporating "implications for adoption" into HCI research practice. Implications for adoption are speculations which may be used in research projects to scrutinize and explore the implications and requirements associated with a technology's potential adoption in the future. There is
Joseph Lindley, Paul Coulton, Miriam Sturdee   +2 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Enhancing Quality of Resident Care and Staff Efficiency Through Implementation of Sensors in the Long-Term Care Setting: A Multi-Site Mixed-Methods Study

Sensors
Introduction: Individuals residing in long-term care facilities (LTCFs) often experience poor sleep quality. Emerging sensor technologies may improve resident sleep quality and reduce staff workload.
Shannon Freeman, Santiago Otalvaro Zapata, Matthew J. Sargent   +2 more
doaj   +1 more source

Driving force of organic fertilizer use in Central Rift Valley of Ethiopia: Independent double hurdle approach [PDF]

Ekonomika Poljoprivrede (1979), 2016
The objective of this study was to identify the important factors that influence both adoption and level of use of organic fertilizer among smallholder farmers in the Central Rift Valley of Ethiopia using a primary data collected from 161 sample ...
Terefe Aemro T., Ahmed Musa H.
doaj   +1 more source