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Chemo-immunotherapy and chemo-adoptive immunotherapy of cancer
Cancer Treatment Reviews, 2001The chemo-immunotherapy (CIT) and chemo-adoptive immunotherapy (CAIT) regimens tested in the past decade are summarized. From them we have learned a great deal about the interactions between various chemotherapeutic agents, immune modulating agents and effector cells.
R.B Hutchison, G.G Gomez, C.A Kruse
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Adoptive Immunotherapy for Malignant Glioma
The Cancer Journal, 2003Despite remarkable advancements in imaging modalities and treatment options available to patients diagnosed with malignant brain tumors, the prognosis for those with high-grade lesions remains poor. The imprecise mechanisms of currently available treatments to manage these tumors do not spare damage to the normal surrounding brain and often result in ...
John H. Sampson +2 more
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Adoptive Immunotherapy in Chimeras [PDF]
, 2003 Depletion of T-cells from the marrow by treatment with absorbed antithymocyte globulin (ATG) prevents GVHD in DLA-identical littermates and transfusion of donor lymphocytes on days 1 and 2, 21 and 22 induces fatal GVHD. However transfusion on days 61 and 62 dose not produce GVHD and the animals survive.
Martin Weber +9 more
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Adoptive immunotherapy of urologic tumors
1989The treatment of humans with advanced cancer represents a major therapeutic challenge. One approach to treating metastatic cancer is immunotherapy, which can be classified into active and passive categories. Active immunotherapy refers to the immunization of the tumor-bearing host with materials that attempt to induce in the host a state of immune ...
Steven A. Rosenberg, Arie S. Belldegrun
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Adoptive immunotherapy of HCMV infection
Cytotherapy, 2007Human cytomegalovirus (HCMV) infection or reactivation is a frequent cause of morbidity and mortality in immunocompromised individuals such as transplant recipients. Primary HCMV infection or reactivation of HCMV from latency is mostly asymptomatic in immunocompetent individuals and is controlled by the host's cell-mediated immune response.
Götz Ulrich Grigoleit +3 more
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Adoptive Immunotherapy for Hodgkin's Lymphoma
International Journal of Hematology, 2006Adoptive transfer of tumor-specific T-cells is an attractive strategy for the treatment of patients with refractory or relapsed Hodgkin's lymphoma. However, Hodgkin's lymphomas possess a range of tumor-evasion mechanisms, which must be overcome before the full potential of immunotherapies can be achieved.
Catherine M. Bollard +2 more
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Costimulatory approaches to adoptive immunotherapy
Current Opinion in Oncology, 1998Costimulation is critical for induction of full T-cell effector function, and thus represents an attractive immunotherapeutic approach for the treatment of cancer. This review examines these approaches, including ex vivo T-cell expansion, systemic "delivery" of constimulation, tumors transduced or transfected with costimulatory ligands, and vaccine ...
Carl H. June +2 more
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Adoptive Immunotherapy of Advanced Melanoma
Current Treatment Options in Oncology, 2012Adoptive cell therapy (ACT) has emerged as an effective therapy for patients with metastatic melanoma. Since the first introduction of the protocol in 1988 [1], major improvements have been achieved with response rates of 40%-72% among patients who were resistant to previous treatment lines.
Ronnie Shapira-Frommer +2 more
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Technological advances in adoptive immunotherapy
Drugs of Today, 2005Adoptive immunotherapy is an attractive and elegant strategy for treating a variety of life-threatening diseases. Several approaches have been developed to generate antigen-specific CD4+ and CD8+ T cells for adoptive T-cell therapy in cancer and infectious diseases.
Christine Krueger +2 more
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Enhancing adoptive immunotherapy of cancer
Expert Opinion on Biological Therapy, 2010Conventional therapies, including surgery, chemotherapy and radiotherapy have contributed much to cancer treatment. However, these treatment modalities fail in a large proportion of patients, and there is a great need for effective alternate therapies.
Phillip K. Darcy +6 more
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