Results 211 to 220 of about 169,984 (290)

Efficacy and Safety of Fixed‐Dose Combinations of Sitagliptin and Empagliflozin as Add‐On to Metformin in Korean Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Multi‐Centre, Placebo‐Controlled, Phase III Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4847-4859, June 2026.
ABSTRACT Background Type 2 diabetes mellitus (T2DM) is a progressive, multi‐organ disorder that often requires intensive combination therapy. This Phase III, randomised, double‐blind, placebo‐controlled study evaluated the efficacy and safety of two fixed‐dose combinations (FDCs) of sitagliptin 100 mg with empagliflozin 10 mg (DW1026C1) or ...
Soo Lim, Tae Nyun Kim, Ji Oh Mok, Choon Hee Chung, You Cheol Hwang, Ho Chan Cho, Jong Chul Won, Eonju Jeon, Eun Seok Kang, Ki Young Lee, Chong Hwa Kim, Soo Heon Kwak, Cheol Young Park, Kang Seo Park, Sang Yong Kim, Jae Hyuk Lee, Soon Hee Lee, Dong Hyeok Cho, Hyuk‐Sang Kwon, Kyung Ah Han   +19 more
wiley   +1 more source

Targeting EphA2 under DNA damage causes mitotic bypass via p21 induction. [PDF]

J Biol Chem
Nakamura A, Tanaka J, Yuki R, Nakayama Y.   +3 more
europepmc   +1 more source

Acalabrutinib in Chronic Lymphocytic Leukemia: Pharmacology and Emerging Clinical Perspectives

European Journal of Haematology, Volume 116, Issue 6, Page 759-770, June 2026.
ABSTRACT Acalabrutinib, a second‐generation Bruton's tyrosine kinase inhibitor (BTKi), is characterized by enhanced specificity and selectivity for BTK with minimal off‐target effects, offering a significant evolution in the treatment of chronic lymphocytic leukemia (CLL). Its mechanism of action, a covalent binding to Cys481 within the BTK active site,
Gianluca Gaidano, Romano Danesi
wiley   +1 more source

Adverse Drug Reactions to Antihypertensive Therapy: A Prospective Evaluation of Causality and Severity Using the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) and Hartwig-Siegel Scales. [PDF]

Cureus
Suneja K, Singh S, Singh S, Kumar R, Kumar N, Dixit R, Sawlani KK, Kumar A, Kumar S, Yadav A, Bhagchandani D.   +10 more
europepmc   +1 more source

The Patterns and Trajectory of Continued Opioid Use in Opioid‐Naïve Patients After Curative‐Intent Elective Cancer Surgery—A Prospective Cohort Study

Pain Practice, Volume 26, Issue 5, June 2026.
ABSTRACT Background Post‐discharge opioid use patterns in opioid‐naïve patients following cancer surgery remain poorly characterized, particularly during the early transition period after discharge. Aim To determine the prevalence of continued opioid use 7 days after discharge and to identify predictors and cessation trajectories over 30 days post ...
Kenny Kwon Ho Lee, Chin Hang Yiu, Jonathan Penm, Amanda Johns   +3 more
wiley   +1 more source

Trends and Patterns of Adverse Drug Reaction Reporting in Sierra Leone: A Retrospective Analysis of VigiFlow Data (2008-2022). [PDF]

Pharmacoepidemiol Drug Saf
Jalloh I, Abiri OT, James PB, Vagiri R, Padayachee N.   +4 more
europepmc   +1 more source

A conceptual model for the diapause intensity curve and termination in overwintering Japanese pine sawyer larvae, Monochamus alternatus (Coleoptera: Cerambycidae)

Physiological Entomology, Volume 51, Issue 2, Page 226-236, June 2026.
Larval diapause intensity of Monochamus alternatus follows a declining curve, beginning with an initial refractory phase and reaching termination after approximately 110 days of chilling at 9°C. Residual inhibitory state strongly influenced post‐chilling development; additional chilling shortened the diapause period more at 18°C than at warmer ...
Myeong Su Go, Soon Hwa Kwon, Dong‐Soon Kim   +2 more
wiley   +1 more source

Incidence and risk factors of adverse drug reactions in multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) regimens containing new drugs: a retrospective study of two national multicenter cohorts. [PDF]

J Thorac Dis
Wang Y, Fu L, Li Z, Liu Y, Li L.
europepmc   +1 more source

Expanding the Phenotype of TAB2‐Related Syndrome: The First Case With Cleft Palate and Insights Into Palatal Development

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1427-1430, June 2026.
Alberto De Rosa, Silvia Kalantari, Marta Carboni, Antonella Casella, Elisa Giorgio, Antonia Apicella, Alessia Claudia Codazzi, Fabio Sirchia   +7 more
wiley   +1 more source

Use of apertures in single‐energy pristine Bragg peak FLASH radiotherapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Abstract Background Proton single‐energy Bragg peak (SEBP) FLASH delivery can achieve dosimetric distributions equivalent to conventional intensity‐modulated proton therapy (IMPT). However, range‐pulling and field compensator devices enlarge the proton pencil beam spot size, increasing lateral penumbra and compromising dose conformality and high‐dose ...
Yangguang Ma, Balaji Selvaraj, Xingyi Zhao, Chingyun Cheng, Chin‐Cheng Chen, Longfei Diao, Yufei Wang, Zhengda Wang, Yuntong Pei, Lele Liu, Xueqing Yan, Benjamin Durkee, Charles B. Simone II, Haibo Lin, Xuanqin Mou, Minglei Kang   +15 more
wiley   +1 more source