Results 311 to 320 of about 805,763 (399)

Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation

iMetaOmics, Volume 2, Issue 4, December 2025.
Microbiota‐gut‐brain axis multiorgan chip and its applications in drug evaluation. The chip includes essential biological components such as gut microbiota, gut barrier, blood‐brain barrier (BBB), and brain. This integrated platform incorporates neural (blue), endocrine (yellow), immune (pink), and metabolic (green) pathways to investigate the impact ...
Yue Tang, Hewen Chen, Ziyue Zhao, Xuesong Kang, Wenxin Wang, Kun Dai, Yufei Guo, Axin Liang, Aiqin Luo, Zikai Hao   +9 more
wiley   +1 more source

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder

International Journal of Methods in Psychiatric Research, Volume 34, Issue 4, December 2025.
ABSTRACT Background Major depressive disorder (MDD) and borderline personality disorder (BPD) are psychiatric conditions with overlapping clinical features but distinct pathologies. This study aims to explore the microvascular changes in superficial retinal capillary plexus (SRCP) in patients between MDD and BPD using Optical Coherence Tomography (OCT)
Qian Xiao, Liying Shen, Fangling Li, Furong Jiang, Bei Xu   +4 more
wiley   +1 more source

Adrenal Insufficiency‐Induced Delirium Following Gastrectomy in a Patient With Gastric Cancer Treated With Nivolumab, Immune Checkpoint Inhibitors: A Case Report

Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
Postoperative hyperactive delirium unmasked secondary adrenal insufficiency in a patient with prior PD‐1 inhibitor exposure. Surgical stress revealed ICI‐related hypophysitis (↓ACTH → ↓cortisol). Hypotension and hypoglycemia prompted endocrine testing (AM cortisol 1.01 μg/dL; ACTH 1.5 pg/mL).
Kazuki Yamada, Taro Sasaki, Tamaki Owada, Kota Kikuchi, Ryo Maehara, Yasushi Kawamata, Norio Sugawara, Norio Yasui‐Furukori   +7 more
wiley   +1 more source

Longitudinal trajectories of major depressive disorder provide further clinical perspectives for precision psychiatry

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Major depressive disorder (MDD) is a common and debilitating disorder. MDD was considered to be a relatively benign disorder compared to other major psychiatric disorders. However, longitudinal research revealed heterogeneous and frequently chronic course.
Murat İlhan Atagün
wiley   +1 more source

Network‐Pluralistic Psychiatry in Epilepsy: A theoretical framework and research agenda for personalized, mechanistic, and integrated care

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Psychiatric comorbidities in epilepsy are prevalent, disabling, and persistently undertreated due to conceptual and operational fragmentation between neurology and psychiatry. This paper proposes Network‐Pluralistic Psychiatry in Epilepsy (NPPE), a hypothesis‐generating, disease‐contextualized framework that integrates four mechanistic layers:
Ryouhei Ishii
wiley   +1 more source